Oral L-arginine protects against cyclosporine-induced hepatotoxicity in rats

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorKurus, Meltem
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorSogutlu, Gokhan
dc.contributor.authorKaya, Mine
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:30:53Z
dc.date.available2024-08-04T20:30:53Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCyclosporine A (CyA) leads to liver injury, probably by causing the production of free radicals and resulting in nitric oxide (NO) deficiency. We evaluated CyA-mediated liver damage histopathologically to determine the possible beneficial effects Of L-arginine (L-Arg). In this study, 7 groups of Sprague-Dawley rats; (1) Control group; (2) 0.9% NaCl group; (3) CyA group: 7.5 mg/kg/day; (4) L-Arg group: 2 g/It/day; (5) L-NAME (N-nitro-L-arginine methyl ester) group: 5mg/100ml/day; (6) CyA+L-Arg group: L-Arg (2 g/It/day) + CyA (7.5mg/kg/day); and (7) CyA + L-NAME group: CyA (7.5mg/kg/day) + L-NAME (5mg/100ml/day) were included. At the end of the treatments, animals were killed and hepatic tissues were treated for morphological (hematoxylin and eosin) and biochemical (NO and malondialdehyde, NIDA) analyses, and serum was processed for biochemical (alanine transaminase (ALT), aspartate transaminase (AST), bilirubin, alkaline phosphatase (ALP) and total protein) study. The results indicated that CyA-induced hepatotoxicity was characterized by sinusoidal dilatation, hepatocellular vacuolization, neutrophilic infiltration and hepatocellular necrosis. These findings were less pronounced in the CyA + L-Arg group than CyA alone group. L-NAME group showed moderate changes. The CyA + L-NAME (Group 7) had more severe changes. We found changes in tissue NO and NIDA levels. We think that the tissue damage caused by CyA is mild and reversible at the period when biochemical parameters are just starting to become abnormal and that L-Arg may have a protective effect against CyA damage on liver. (C) 2008 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.etp.2008.04.007
dc.identifier.endpage419en_US
dc.identifier.issn0940-2993
dc.identifier.issn1618-1433
dc.identifier.issue4-5en_US
dc.identifier.pmid18583116en_US
dc.identifier.scopus2-s2.0-46649097990en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://doi.org/10.1016/j.etp.2008.04.007
dc.identifier.urihttps://hdl.handle.net/11616/94587
dc.identifier.volume60en_US
dc.identifier.wosWOS:000258457600022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofExperimental and Toxicologic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyAen_US
dc.subjectnitric oxideen_US
dc.subjectL-argen_US
dc.subjectL-NAMEen_US
dc.subjecthepatotoxicityen_US
dc.titleOral L-arginine protects against cyclosporine-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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