Estimating the age of Hb G-Coushatta [22(B4)GluAla] mutation by haplotypes of -globin gene cluster in Denizli, Turkey

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dc.authoridOZTURK, Onur/0000-0003-3404-4135
dc.authorwosidATALAY, AYFER/HKO-1963-2023
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.authorwosidOZTURK, Onur/HLH-4990-2023
dc.contributor.authorOzturk, Onur
dc.contributor.authorArikan, Sanem
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorAtalay, Erol O.
dc.date.accessioned2024-08-04T20:44:27Z
dc.date.available2024-08-04T20:44:27Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackgroundHb G-Coushatta variant was reported from various populations' parts of the world such as Thai, Korea, Algeria, Thailand, China, Japan and Turkey. In our study, we aimed to discuss the possible historical relationships of the Hb G-Coushatta mutation with the possible migration routes of the world. For this purpose, associated haplotypes were determined using polymorphic loci in the beta globin gene cluster of hemoglobin G-Coushatta and normal populations in Denizli, Turkey. MethodsWe performed statistical analysis such as haplotype analysis, Hardy-Weinberg equilibrium, measurement of genetic diversity and population differentiation parameters, analysis of molecular variance using F-statistics, historical-demographic analyses, mismatch distribution analysis of both populations and applied the test statistics in Arlequin ver. 3.5 software program. ResultsThe diversity of haplotypes has been shown to indicate different genetic origins for two populations. However, AMOVA results, molecular diversity parameters and population demographic expansion times showed that the Hb G-Coushatta mutation develops on the normal population gene pool. Our estimated values showed the average time since the demographic expansion for normal and Hb G-Coushatta populations ranged from approximately 42,000 to 38,000 ybp, respectively. ConclusionOur data suggest that Hb G-Coushatta population originate in normal population in Denizli, Turkey. These results support the hypothesis that the multiple origin of Hb G-Coushatta and indicate that mutation may have been triggered the formation of new variants on beta globin haplotypes.en_US
dc.identifier.doi10.1002/mgg3.404
dc.identifier.endpage554en_US
dc.identifier.issn2324-9269
dc.identifier.issue4en_US
dc.identifier.pmid29717566en_US
dc.identifier.scopus2-s2.0-85046136098en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://doi.org/10.1002/mgg3.404
dc.identifier.urihttps://hdl.handle.net/11616/98259
dc.identifier.volume6en_US
dc.identifier.wosWOS:000441004000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMolecular Genetics & Genomic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbeta-globin geneen_US
dc.subjecthaplotypeen_US
dc.subjectHb G-Coushattaen_US
dc.subjectmutation age estimateen_US
dc.subjectpopulation genetic structureen_US
dc.titleEstimating the age of Hb G-Coushatta [22(B4)GluAla] mutation by haplotypes of -globin gene cluster in Denizli, Turkeyen_US
dc.typeArticleen_US

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