Photocrosslinkable gelatin/collagen based bioinspired polyurethane-acrylate bone adhesives with biocompatibility and biodegradability

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dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorGurses, Canbolat
dc.contributor.authorOzcan, Imren
dc.contributor.authorYildiz, Azibe
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:50:44Z
dc.date.available2024-08-04T20:50:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHard or soft tissue adhesives have been presented as a promising candidate to replace traditional wound closure methods. However, there are mechanical strength problems in biological adhesives and biocompatibility problems in synthetic-based adhesives. At this point, we aimed to remove all these disadvantages and produce a single adhesive that contains all the necessary features and acrylate functionalized UV-curable polyurethane formulations were produced with high crosslink density, high adhesion strength, biocompatibility and injectable property for easy application as potential biomedical adhesives. Aliphatic isophorone diisocyanate (IPDI) was used as the isocyanate source and beta-cyclodextrin was used for host-guest relationship with gentamicin by crosslinking. Proteins (gelatin (GEL), collagen (COL)) and PEGs of various molecular weight ranges (P200, P400, P600) were selected as the polyol backbone for polyurethane synthesis due to their multiple biological activities such as biocompatibility, biodegradability, biomimetic property. Several techniques have been used to characterize the structural, thermal, morphological, and various other physicochemical properties of the adhesive formulations. Besides, the possibility of its use as a hard tissue adhesive was investigated by evaluating the tissue adhesion strength in vitro and ex vivo via a universal testing analyzer in tensile mode. Corresponding adhesive formulations were evaluated by in vitro and in vivo techniques for biocompatibility. The best adhesion strength results were obtained as 3821.0 +/- 214.9, and 3722.2 +/- 486.8 kPa, for IPDI-COL-P200 and IPDI-GEL-P200, respectively. Good antibacterial activity capability toward Escherichia coli Pseudomonas aeruginosa, and Staphylococcus aureus were confirmed using disc diffusion method. Moreover, cell viability assay demonstrated that the formulations have no significant cytotoxicity on the L929 fibroblast cells. Most importantly, we finally performed the in vivo biodegradability and in vivo biocompatibility evaluations of the adhesive formulations on rat model. Considering their excellent cell/tissue viability, fast curable, strong adhesion, high antibacterial character, and injectability, these adhesive formulations have significant potential for tissue engineering applications.en_US
dc.description.sponsorshipScientific and Techno-logical Research Council of Turkey [116Z501]; Inonu University [FDP-2018-1284]en_US
dc.description.sponsorshipThis work was supported financially by the Scientific and Techno-logical Research Council of Turkey [No. 116Z501] and Inonu University [No. FDP-2018-1284] .en_US
dc.identifier.doi10.1016/j.ijbiomac.2021.09.043
dc.identifier.endpage1356en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid34536477en_US
dc.identifier.scopus2-s2.0-85116703567en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1344en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.09.043
dc.identifier.urihttps://hdl.handle.net/11616/100252
dc.identifier.volume192en_US
dc.identifier.wosWOS:000729181200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone adhesiveen_US
dc.subjectPolyurethane-acrylateen_US
dc.subjectGelatin, collagen, UV-curingen_US
dc.subjectAntibacterial activityen_US
dc.subjectBiodegradabilityen_US
dc.subjectFlexibilityen_US
dc.subjectBiocompatibilityen_US
dc.titlePhotocrosslinkable gelatin/collagen based bioinspired polyurethane-acrylate bone adhesives with biocompatibility and biodegradabilityen_US
dc.typeArticleen_US

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