Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats

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dc.contributor.authorYilmaz, Umit
dc.contributor.authorTekin, Suat
dc.contributor.authorDemir, Mehmet
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2019-06-24T06:07:16Z
dc.date.available2019-06-24T06:07:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the impact of intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic-pituitary-thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used and divided into three groups including control, sham (vehicle) and FGF21 infused groups (n = 10). Intracerebroventricularly, FGF21 and vehicle groups were infused for 7 days with FGF21 (0.72 mu g/day) and artificial cerebrospinal fluid, respectively. During the experimental period, changes in food intake and body weight were recorded daily. Serum thyroid stimulating hormone (TSH), Triiodothyronine (T3) and thyroxine (T4) levels were measured using ELISA. TRH and uncoupling protein 1 (UCP1) gene expressions were analyzed by using RT-PCR in hypothalamus and adipose tissues, respectively. Chronic infusion of FGF21 significantly increased serum TSH (p < 0.05), T3 (p < 0.05) and T4 (p < 0.001) levels. Additionally, hypothalamic TRH (p < 0.05) and UCP1 gene expressions (p<0.05) in white adipose tissue were found to be higher than in the vehicle and control groups. While FGF21 infusion did not cause a significant change in food consumption, it caused a reduction in the body weight of rats (p < 0.05). Our findings indicate that FGF21 may have an effect on energy metabolism via the HPT axis.en_US
dc.identifier.citationYilmaz, U. Tekin, S. Demir, M. Cigremis, Y . Sandal, S . (2018). Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats. Cilt:68. Sayı:6. 781-788ss.en_US
dc.identifier.doi10.1007/s12576-018-0595-7en_US
dc.identifier.endpage788en_US
dc.identifier.issue6en_US
dc.identifier.startpage781en_US
dc.identifier.urihttps://hdl.handle.net/11616/12003
dc.identifier.volume68en_US
dc.language.isoenen_US
dc.publisherJournal of physıologıcal scıencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrowth-Factor 21en_US
dc.subjectInsulın Sensıtıvıtyen_US
dc.subjectBody-Weıghten_US
dc.subjectPpar-Alphaen_US
dc.subjectExpendıtureen_US
dc.subjectExpressıonen_US
dc.subjectPharmacologyen_US
dc.subjectContrıbutesen_US
dc.subjectHomeostasısen_US
dc.subjectRegulatoren_US
dc.titleEffects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in ratsen_US
dc.typeArticleen_US

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