Effects of aminoguanidine against renal ischaemia-reperfusion injury in rats

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dc.authoridCihan, Omer Faruk/0000-0001-5290-4384
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidCihan, Omer Faruk/T-7727-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorCihan, OF
dc.contributor.authorTurkoz, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:15:21Z
dc.date.available2024-08-04T20:15:21Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoforrn (iNOS). In addition to being all inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that aminoguanidine reduces ischaemia-reperfusion (I/R)-induced damage. However, the role of aminoguanidine, in renal injury associated with I/R remains unknown. This Study was designed to investigate the effects of aminoguanidine on renal I/R injury. There were three groups of eight rats each. I/R was induced by occlusion of the left renal vessels for 60 min, followed by 24 h reperfusion in rats. Malondialdehyde (MDA) levels, a stable metabolite of the free radical-mediated lipid peroxidation cascade, were found to be significantly higher in the I/R group (30.3 +/- 0.1 nmol g(-1) tissue) than in the control group (10 +/- 0.05 nmol g(-1)). Aminoguanidine (100 mg kg(-1)) administration to rats significantly reduced the MDA values. We also demonstrated that I/R leads to structural change but aminoguanidine did not reverse this change. Aminoguanidine, according to the biochemical finding is protective but histopathological findings did not reveal protection against I/R injury in kidney. The effects of aminoguanidine on I/R-induced damage remain a subject for future investigations. Copyright (c) 2004 John Wiley & Soils, Ltd.en_US
dc.identifier.doi10.1002/cbf.1196
dc.identifier.endpage141en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue2en_US
dc.identifier.pmid15617031en_US
dc.identifier.scopus2-s2.0-33645326250en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1196
dc.identifier.urihttps://hdl.handle.net/11616/94328
dc.identifier.volume24en_US
dc.identifier.wosWOS:000236399600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminoguanidineen_US
dc.subjectischaemiaen_US
dc.subjectreperfusionen_US
dc.subjectkidneyen_US
dc.titleEffects of aminoguanidine against renal ischaemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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