Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats

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dc.authoridYILMAZ, Fethi/0000-0002-5041-9390
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridTimurkaan, Necati/0000-0001-5567-991X
dc.authorwosidYILMAZ, Fethi/W-9442-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidTimurkaan, Necati/V-7016-2018
dc.contributor.authorOguzturk, H.
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.contributor.authorTimurkaan, N.
dc.contributor.authorBeytur, A.
dc.contributor.authorYilmaz, F.
dc.date.accessioned2024-08-04T20:36:00Z
dc.date.available2024-08-04T20:36:00Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the ameliorative effect of curcumin (CMN) against acute cadmium chloride (CdCl2) toxicity on male reproductive system in rats. CdCl2 is known to be a heavy metal and potential environmental pollutant. For this purpose, 28 rats were equally divided into four groups; the first group was kept as control and given distilled water and corn oil as carrier. In second and third groups, CdCl2 and CMN were administered at the dose with 1 mg kg-1 day-1 and 100 mg kg-1 for 3 days respectively. CdCl2 and CMN were given together at the same doses in the fourth group. It was determined that acute CdCl2 exposure caused a significant reproductive damage via increased oxidative stress (increased TBARS levels and decreased SOD, CAT, GPx and GSH levels), histological alterations (necrosis, oedema etc.) and spermatological damage (decreased sperm motility and sperm concentration and increased abnormal sperm rate) in male rats. However, CMN treatment partially reversed these toxic effects of CdCl2 on the reproductive system. In conclusion, our results show that acute exposure of CdCl2 may lead to infertility, and CMN could prevent and reverse hazardous effects of CdCl2 to some degree. Thus, CMN may be useful for the prevention of CdCl2-induced reproductive damage.en_US
dc.identifier.doi10.1111/j.1439-0272.2012.01273.x
dc.identifier.endpage249en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid22257170en_US
dc.identifier.scopus2-s2.0-84863224322en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2012.01273.x
dc.identifier.urihttps://hdl.handle.net/11616/95709
dc.identifier.volume44en_US
dc.identifier.wosWOS:000305822400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcadmium chlorideen_US
dc.subjectcurcuminen_US
dc.subjectoxidative stressen_US
dc.subjectsperm parametersen_US
dc.subjecttesticular damageen_US
dc.titleAmeliorative effects of curcumin against acute cadmium toxicity on male reproductive system in ratsen_US
dc.typeArticleen_US

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