Mide kanseri tanılı hastalarda demografik veriler ve klinik özelliklerin retrospektif değerlendirilmesi
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada; mide kanseri tanılı hastaların demografik verileri ve klinik özelliklerinin retrospektif değerlendirilmesi yapıldı. Gereç ve Yöntem: Bu çalışmada 01.01.2010-10.10.2017 tarihleri arasında İnönü Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Bilim Dalı'nda mide kanseri tanısı ile takip edilen 230 hastanın verileri incelendi. Lenfoma, gastrointestinal stromal tümör ve nöroendokrin tümör (NET) tanılı hastalar çalışma dışı tutuldu. Kalan 201 hasta çalışmaya alındı. Çalışmaya dahil edilen 201 hastada yaş, cinsiyet, Eastern Cooperative Oncology Group (ECOG), kilo kaybı varlığı, primer yeri, histolojik tip, tümör evresi, hastanın başvuruya sebep olan yakınması, sigara içiciliği, semptom süresi, tanı metodu, cerrahi yapılıp yapılmadığı, cerrahi şekli, metastaz varlığı, metastaz yeri, ilk bakılan LDH ve trombosit değerleri, uygulanan tedavi yöntemleri, genel sağkalım (GS) verileri değerlendirildi. Bulgular ve Sonuç: Araştırmamız neticesinde erkek hastaların oranı kadın hastalara göre, istatistiksel olarak anlamlı yüksek tespit edilmiştir. Hasta yaşı ile ortalama GS arasında anlamlı ilişki saptandı (p=0.014). Kilo kaybı ile ileri evre arasındaki ilişki istatistiksel olarak analiz edildi ve anlamlı fark saptandı (p=0.005). Kilo kaybı ile ortalama GS arasında da anlamlı fark vardı (p<0.001). ECOG ile ortalama GS arasında anlamlı fark vardı (p=0.008). LDH değeri ile ortalama GS arasında anlamlı fark vardı (p<0.001). Çalışmamızda ileri evrede GS'ın azaldığı görüldü (p<0.001). Tümörün primer yerleşim yeri ile ortalama GS arasında anlamlı ilişki saptandı (p=0.007). Kemoterapi (KT) alan ve almayan hastalarla ortalama GS arasında anlamlı ilişki vardı (p=0.003). Adjuvan KT ve palyatif amaçlı KT alan hasta gruplarının GS ile ilişkisi incelendi. İstatistiksel olarak anlamlı ilişki saptandı (p<0.001). Verilen KT çeşidi ile ortalama GS arasında anlamlı ilişki bulundu (p=0.035). Cerrahi ile ortalama GS arasında anlamlı fark vardı (p<0.001). Radyoterapi (RT) ile ortalama GS arasında anlamlı fark vardı (p<0.001). GS üzerine etkisi anlamlı olduğu belirlenen bağımsız değişkenler çok değişkenli Cox- Regresyon modeli kullanılarak araştırıldı. Araştırma sonucuna göre cerrahi, LDH değeri, kilo kaybı ve metastaz varlığının bağımsız prognostik faktörler olduğu tespit edildi (p=0.005, p=0.048, p=0.014, p=0.005). Anahtar Kelimeler: Mide kanseri, demografik veriler, genel sağkalım Anahtar Kelimeler: Mide kanseri, demografik veriler, genel sağkalım
Purpose: In this study; The demographic data and clinical features of patients with gastric cancer were retrospectively evaluated. Material and Method: In this study; 230 patients who were followed up with the diagnosis of gastric cancer in the Medical Oncology Department of İnönü University between 01.01.2010 and 10.10.2017 were examined. Patients with lymphoma, GİST and NET were excluded from the study. The remaining 201 patients were included in the study. 201 patients included in the study age, Eastern Cooperative Oncology Group (ECOG), presence of weight loss, primary site, histological type, tumor stage, patient's complaint, smoking, symptom duration, diagnostic method, surgery, surgical method, presence of metastasis, location of metastasis, first looked LDH and thrombocyte values, treatment methods and survival data were evaluated. Results and Conclusion: As a result of our study, male patients were found to be statistically significantly higher than female patients. There was a significant relationship between patient age and mean overall survival (p=0.014). The relationship between weight loss and advanced stage was statistically analyzed and a significant difference was found (p=0.005). There was also a significant difference between weight loss and mean overall survival (p <0.001). There was a significant difference between ECOG and mean overall survival (p=0.008). There was a significant difference between LDH value and mean overall survival (p <0.001). In our study, it was seen that overall survival decreased in advanced stage (p<0.001). Significant correlation was found between the primary site of tumor and mean overall survival (p=0.007). There was a significant relationship between the average survival rate and the patients with and without chemotherapy (p=0.003). The relationship between overall survival and adjuvant chemotherapy and palliative chemotherapy was investigated. A statistically significant relationship was found (p<0.001). Significant relationship was found between the type of chemotherapy and mean overall survival (p<0.035). There was a significant difference between surgery and mean overall survival (p<0.001). There was a significant difference between radiation therapy and mean overall survival (p<0.001). The independent variables which had significant effect on mean overall survival were investigaed using the multivariate Cox- Regression model. According to the results of the study, it was determined that the presence of surgery, LDH, weight loss and metastasis were independent prognostic factors. (p=0.005, p=0.048, p=0.014, p=0.005). Keywords: Gastric cancer, demographic data, overall survival Keywords: Gastric cancer, demographic data, overall survival
Purpose: In this study; The demographic data and clinical features of patients with gastric cancer were retrospectively evaluated. Material and Method: In this study; 230 patients who were followed up with the diagnosis of gastric cancer in the Medical Oncology Department of İnönü University between 01.01.2010 and 10.10.2017 were examined. Patients with lymphoma, GİST and NET were excluded from the study. The remaining 201 patients were included in the study. 201 patients included in the study age, Eastern Cooperative Oncology Group (ECOG), presence of weight loss, primary site, histological type, tumor stage, patient's complaint, smoking, symptom duration, diagnostic method, surgery, surgical method, presence of metastasis, location of metastasis, first looked LDH and thrombocyte values, treatment methods and survival data were evaluated. Results and Conclusion: As a result of our study, male patients were found to be statistically significantly higher than female patients. There was a significant relationship between patient age and mean overall survival (p=0.014). The relationship between weight loss and advanced stage was statistically analyzed and a significant difference was found (p=0.005). There was also a significant difference between weight loss and mean overall survival (p <0.001). There was a significant difference between ECOG and mean overall survival (p=0.008). There was a significant difference between LDH value and mean overall survival (p <0.001). In our study, it was seen that overall survival decreased in advanced stage (p<0.001). Significant correlation was found between the primary site of tumor and mean overall survival (p=0.007). There was a significant relationship between the average survival rate and the patients with and without chemotherapy (p=0.003). The relationship between overall survival and adjuvant chemotherapy and palliative chemotherapy was investigated. A statistically significant relationship was found (p<0.001). Significant relationship was found between the type of chemotherapy and mean overall survival (p<0.035). There was a significant difference between surgery and mean overall survival (p<0.001). There was a significant difference between radiation therapy and mean overall survival (p<0.001). The independent variables which had significant effect on mean overall survival were investigaed using the multivariate Cox- Regression model. According to the results of the study, it was determined that the presence of surgery, LDH, weight loss and metastasis were independent prognostic factors. (p=0.005, p=0.048, p=0.014, p=0.005). Keywords: Gastric cancer, demographic data, overall survival Keywords: Gastric cancer, demographic data, overall survival
Açıklama
Anahtar Kelimeler
Onkoloji, Oncology
