Independent predictive factors for the persistence and tolerance of cow's milk allergy

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authoridTonbul, Hayrettin/0000-0001-5510-8973
dc.authoridDuman, Yucel/0000-0002-9090-2096
dc.authoridDemirtas, Mehmet Semih/0000-0003-2965-1811
dc.authoridtopal, erdem/0000-0002-4439-2689
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.authorwosidTonbul, Hayrettin/AAR-6961-2020
dc.authorwosidCeliksoy, Mehmet Halil/A-3889-2015
dc.authorwosidDuman, Yucel/AAU-6221-2020
dc.authorwosidDemirtas, Mehmet Semih/GPX-1111-2022
dc.authorwosidtopal, erdem/ABI-7545-2020
dc.contributor.authorTopal, Erdem
dc.contributor.authorCeliksoy, Mehmet Halil
dc.contributor.authorArga, Mustafa
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorDuman, Yucel
dc.contributor.authorDemirtas, Semih
dc.contributor.authorAlatas, Cem
dc.date.accessioned2024-08-04T20:45:31Z
dc.date.available2024-08-04T20:45:31Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Cow's milk protein allergy (CMPA) is usually transient, with most children tolerating ingested cow's milk by 3 years of age. This study aimed to determine factors that promote or hindering the development of tolerance to CMPA. Methods A logistic regression model was used to determine independent risk factors associated with tolerance and persistence of CMPA. Result A total of 178 children diagnosed with CMPA were included in the study. The patients' median age was 32 months (minimum-maximum, 14 to 144 months), and their median follow-up period was 30 months (minimum-maximum, 12 to 54 months). In the follow-up, CMPA persisted in 62 (34.8%) patients. The patients were divided into 2 groups according to patient's age. Group I was <3 years old and group II was >= 3 years old. The factors independently associated with the persistence of CMPA for group I were as follows: comorbid food allergies (p = 0.021), the presence of an immunoglobulin E (IgE)-mediated reaction (p = 0.001), and respiratory system symptoms (ie, tachypnea) (p = 0.036). The presence of gastrointestinal-related discomfort (p = 0.001) was an independent risk factor associated with the development of tolerance. The presence of comorbid food allergies (p = 0.03) was the only independent predictive factor for CMPA persistence for group II. Conclusion The prognosis in cases of CMPA, a food allergy, is good, with tolerance developing over time. The presence of IgE-mediated CMPA, respiratory-related symptoms (ie, tachypnea), and the presence of comorbid food allergies have negative effects on tolerance.en_US
dc.identifier.doi10.1002/alr.22227
dc.identifier.endpage71en_US
dc.identifier.issn2042-6976
dc.identifier.issn2042-6984
dc.identifier.issue1en_US
dc.identifier.pmid30376614en_US
dc.identifier.scopus2-s2.0-85055869543en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.1002/alr.22227
dc.identifier.urihttps://hdl.handle.net/11616/98518
dc.identifier.volume9en_US
dc.identifier.wosWOS:000454763600011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Forum of Allergy & Rhinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectallergyen_US
dc.subjectcow's milken_US
dc.subjectpersistenceen_US
dc.subjectpredictive factorsen_US
dc.subjecttoleranceen_US
dc.titleIndependent predictive factors for the persistence and tolerance of cow's milk allergyen_US
dc.typeArticleen_US

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