Synthesis, characterization, in vitro antibacterial, and anticancer studies of Ag(I)-N-heterocyclic carbene (NHC) complexes

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorUlu, Oznur Dogan
dc.contributor.authorKurucay, Ali
dc.contributor.authorAtes, Burhan
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:53:02Z
dc.date.available2024-08-04T20:53:02Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN-Heterocyclic carbene (NHC) complexes of metals such as Ag(I), Au(I), Pd(II), and Cu(I) are very interesting compounds due to both their catalytic and biological properties. In particular, Ag(I)-NHC complexes show activity as antibacterial, antimicrobial, and anticancer agents. Therefore, in this study, six new Ag(I) complexes were obtained from the reaction of benzimidazolium salts with Ag2O. The structures of the prepared compounds were elucidated by FT-IR, H-1 NMR, C-13 NMR, LC-MS spectroscopic methods, and elemental analysis. The antibacterial activity of all Ag(I)-NHC complexes was evaluated against bacterial strains E. coli as gram-negative and B. subtilis as gram-positive bacteria using ampicillin as a standard antibiotic. Moreover, all Ag(I)-NHC complexes were investigated for anticancer activity against the breast adenocarcinoma cell line (MCF-7). All complexes showed good activity against two bacterial strains, even complexes 2d and 2e had more bactericidal activity against B. subtilis than ampicillin. Moreover, complexes 2a (IC50 6.01 +/- 2.39 mu g/mL) and 2e (IC50 3.40 +/- 0.87 mu g/mL) exhibited a better anticancer effect against to MCF-7 cell line than cisplatin (IC50 82.02 +/- 6.19 mu g/mL). Finally, it is worthy to note that the biochemical outcomes revealed that these complexes may be promising antibacterial and anticancer agents.en_US
dc.description.sponsorshipInonu University Research Fund [FBG-2021-2562]en_US
dc.description.sponsorshipThis work was financially supported by the Inonu University Research Fund (.IU-BAP: FBG-2021-2562).en_US
dc.identifier.doi10.1007/s11696-022-02498-1
dc.identifier.endpage435en_US
dc.identifier.issn0366-6352
dc.identifier.issn2585-7290
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85138730960en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1007/s11696-022-02498-1
dc.identifier.urihttps://hdl.handle.net/11616/100911
dc.identifier.volume77en_US
dc.identifier.wosWOS:000857287500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofChemical Papersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbineen_US
dc.subjectSilver complexesen_US
dc.subjectAntibacterial activityen_US
dc.subjectBreast cancer cellsen_US
dc.subjectCytotoxic activityen_US
dc.titleSynthesis, characterization, in vitro antibacterial, and anticancer studies of Ag(I)-N-heterocyclic carbene (NHC) complexesen_US
dc.typeArticleen_US

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