Therapeutic effects of dexpanthenol on the cardiovascular and respiratory systems following cecal ligation and puncture-induced sepsis in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridKose, Adem/0000-0002-1853-1243
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidKose, Adem/AAD-1226-2020
dc.contributor.authorKose, Adem
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOzhan, Onural
dc.contributor.authorErmis, Necip
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorCigremis, Yilmaz
dc.date.accessioned2024-08-04T20:47:07Z
dc.date.available2024-08-04T20:47:07Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCecal ligation and puncture (CLP) is a commonly used model of sepsis in vivo. We investigated the effects of dexpanthenol (DXP) on heart, lung and aorta in CLP-induced sepsis in rats. Rats were divided into four groups of eight: group 1, sham (SH); group 2 (DXP), 500 mg/kg DXP injected intraperitoneally (i.p.); group 3 (CLP), CLP performed; group 4 (CLP + DXP), 500 mg/kg DXP injected i.p. after CLP. Heart, lung and aorta specimens were harvested for histopathological and biochemical analysis. Heart rate increased in group 3 compared to group 1; DXP administration to group 4 did not alleviate this change. In heart tissue samples, MDA levels were decreased signi?cantly in groups 2 and 4 compared to group 3. The levels of GSH in groups 2 and 3 were elevated compared to groups 1 and 2. SOD activity was increased significantly in group 4 compared to group 3. CAT activity for group 4 was increased significantly compared to groups 1 and 3. We found that caspase-9 and caspase-3 activity was increased after application of CLP. Also, DXP treatment decreased the number of caspase-positive cells significantly compared to group 3. DXP appears to be promising for reducing sepsis-related mortality.en_US
dc.description.sponsorshipScientific Research Projects Unit, Inonu University [BAP 2016-187]en_US
dc.description.sponsorshipOur study was supported by Scientific Research Projects Unit, Inonu University, grant number: BAP 2016-187.en_US
dc.identifier.doi10.1080/10520295.2020.1714078
dc.identifier.endpage437en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid32043372en_US
dc.identifier.scopus2-s2.0-85079419563en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1714078
dc.identifier.urihttps://hdl.handle.net/11616/99180
dc.identifier.volume95en_US
dc.identifier.wosWOS:000513457700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidanten_US
dc.subjectcecumen_US
dc.subjectdexpanthenolen_US
dc.subjectligationen_US
dc.subjectpunctureen_US
dc.subjectraten_US
dc.subjectsepsisen_US
dc.titleTherapeutic effects of dexpanthenol on the cardiovascular and respiratory systems following cecal ligation and puncture-induced sepsis in ratsen_US
dc.typeArticleen_US

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