Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced?

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorSahna, E
dc.contributor.authorOlmez, E
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:12:22Z
dc.date.available2024-08-04T20:12:22Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCardiac arrhythmias during ischemia-reperfusion (I/R) are believed to be related to free radicals generated in the heart especially during the period of reperfusion. The pineal secretory product. melatonin, is known to be a potent free radical scavenger and its pharmacological concentrations have been shown to reduce the I/R-induced arrhythmias in isolated rat hearts. However, the physiological role of melatonin in the prevention of these arrhythmias is unknown. Rats were pinealectomized (Px) or sham-operated (non-Px) (control) 2 months before the I/R studies. To produce arrhythmias. left main coronary artery was occluded for 7 min, followed by 7 min reperfusion, in anesthetized rats. The incidence of mortality resulted from irreversible ventricular fibrillation (VF) was found significantly higher in the Px rats (63%) than in the control group (25%). Melatonin administration (0.4 mg,kg, either before ischemia or reperfusion) to Px rats significantly reduced the incidence of total (irreversible plus reversible) and irreversible VF and returned them to control values. On the other hand, melatonin administration (0.4 and 4 mg/kg) to non-Px rats failed to attenuate the I/R arrhythmias, significantly. These results suggest that physiological melatonin concentrations are important to reduce the I/R-induced VF and mortality. while pharmacological concentrations of melatonin did not increase its beneficial effect on these arrhythmias. As melatonin levels have been reported to decrease with age, melatonin replacement therapy may attenuate the incidence of sudden cardiac death especially in older patients,en_US
dc.identifier.doi10.1034/j.1600-079x.2002.1o853.x
dc.identifier.endpage198en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue3en_US
dc.identifier.pmid12074104en_US
dc.identifier.scopus2-s2.0-0036223583en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079x.2002.1o853.x
dc.identifier.urihttps://hdl.handle.net/11616/93393
dc.identifier.volume32en_US
dc.identifier.wosWOS:000175102200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectraten_US
dc.subjectreperfusion arrhythmiasen_US
dc.titleEffects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced?en_US
dc.typeArticleen_US

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