Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

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dc.authoridYolbaş, Servet/0000-0001-8516-9769
dc.authoridDENİZ, GÜLNİHAL/0000-0002-5944-8841
dc.authoridkaratas, ahmet/0000-0002-6725-4182
dc.authoridCelik, Zulfinaz Betul/0000-0003-1390-7309
dc.authorwosidYolbaş, Servet/ABI-5312-2020
dc.authorwosidDENİZ, GÜLNİHAL/GZA-5661-2022
dc.authorwosidkaratas, ahmet/E-7046-2016
dc.authorwosidÖz, Burak/HJP-5975-2023
dc.contributor.authorOz, Burak
dc.contributor.authorYildirim, Ahmet
dc.contributor.authorYolbas, Servet
dc.contributor.authorCelik, Zulfinaz Betul
dc.contributor.authorEtem, Ebru Onalan
dc.contributor.authorDeniz, Gulnihal
dc.contributor.authorAkin, Mustafa
dc.date.accessioned2024-08-04T20:45:34Z
dc.date.available2024-08-04T20:45:34Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractResveratrol, a phytochemical, acts several cellular signaling pathways and has anti-inflammatory potentials. The purpose of this study is to research the therapeutic effect of resveratrol in collagen-induced arthritis (CIA) model in rats and whether resveratrol affects the activities of signaling pathways those are potent pathogenic actors of rheumatoid arthritis. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant in Wistar albino rats. One day after the onset of arthritis (day 14), resveratrol (20 mg/kg/day) was given via oral gavage, until day 29. The paws of the rats were obtained for further analysis. Tissue Wnt5a, mitogen-activated protein kinase (MAPK), Src tyrosine kinase and signal transducer, and activator of transcription-3 (STAT3) mRNA expressions were determined by real-time polymerase chain reaction. Resveratrol ameliorated the clinical and histopathological (perisynovial inflammation and cartilage-bone destruction) findings of inflammatory arthritis. The tissue mRNA expressions of Wnt5a, MAPK3, Src kinase, and STAT3 were increased in the sham group compared to the control group. Resveratrol supplement decreased their expressions. The present study shows that Src kinase, STAT3, and Wnt signaling pathway are active in the CIA model. Resveratrol inhibits these signaling pathways and ameliorates inflammatory arthritis. (c) 2018 BioFactors, 45(1):69-74, 2019en_US
dc.identifier.doi10.1002/biof.1463
dc.identifier.endpage74en_US
dc.identifier.issn0951-6433
dc.identifier.issn1872-8081
dc.identifier.issue1en_US
dc.identifier.pmid30496633en_US
dc.identifier.scopus2-s2.0-85057808769en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1002/biof.1463
dc.identifier.urihttps://hdl.handle.net/11616/98558
dc.identifier.volume45en_US
dc.identifier.wosWOS:000457830400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBiofactorsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectcollagen induced arthritisen_US
dc.subjectresveratrolen_US
dc.titleResveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis modelen_US
dc.typeArticleen_US

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