Molecular characterization of carbapenem-resistant Enterobacteriaceae yields increasing rates of NDM-1 carbapenemases and colistin resistance in an OXA-48-endemic area

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridaktas, elif/0000-0003-3087-5425
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidaktas, elif/ACL-9792-2022
dc.authorwosidÇizmeci, Zeynep/JXW-5636-2024
dc.contributor.authorCizmeci, Zeynep
dc.contributor.authorAktas, Elif
dc.contributor.authorOtlu, Baris
dc.contributor.authorAcikgoz, Ozlem
dc.contributor.authorOrdekci, Seyhan
dc.date.accessioned2024-08-04T20:43:10Z
dc.date.available2024-08-04T20:43:10Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to characterize carbapenem-resistant isolates in a tertiary hospital in Istanbul, Turkey, high-prevelance area for OXA-48 producers. About 76 Enterobacteriaceae clinical isolates were included. Carbapenemase production was detected by Carbapenem Inactivation Method and carbapenemase genes were investigated by PCR. The clonal relationships were evaluated by AP-PCR. Nineteen Klebsiella pneumoniae isolates were colistin resistant. About 75 isolates yielded carbapenemase by CIM. 52 OXA-48, 17 NDM-1 and 2 VIM-5 carbapenemase genes were detected. Co-production of 'OXA-48 and NDM-1' and 'OXA-48 and VIM-5' were demonstrated in two Klebsiella pneumoniae isolates. The total clustering rate was 20.2%. About 69 Klebsiella pneumoniae yielded 60 profiles and 12 isolates formed five clusters. We have demonstrated the presence of OXA-48 carbapenemases in the majority of isolates in a large collection of carbapenemase-producing isolates from a single hospital. The relatively high rates of NDM-1-producing isolates and colistin resistance is noteworthy.en_US
dc.identifier.doi10.1080/1120009X.2017.1323149
dc.identifier.endpage350en_US
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue6en_US
dc.identifier.pmid28486840en_US
dc.identifier.scopus2-s2.0-85019135186en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.1080/1120009X.2017.1323149
dc.identifier.urihttps://hdl.handle.net/11616/97813
dc.identifier.volume29en_US
dc.identifier.wosWOS:000423162200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectCarbapenemasesen_US
dc.subjectMolecular characterizationen_US
dc.subjectOXA-48en_US
dc.subjectNDM-1en_US
dc.subjectColistin resistanceen_US
dc.titleMolecular characterization of carbapenem-resistant Enterobacteriaceae yields increasing rates of NDM-1 carbapenemases and colistin resistance in an OXA-48-endemic areaen_US
dc.typeArticleen_US

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