Factors affecting the accuracy of 18F-FDG PET/CT in evaluating axillary metastases in invasive breast cancer

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dc.authoridKutluturk, Koray/0000-0002-7030-4953
dc.authoridSimsek, Arife/0000-0002-4807-3597
dc.authorwosidKutluturk, Koray/S-5493-2019
dc.authorwosidSimsek, Arife/AAB-3245-2021
dc.contributor.authorKutluturk, K.
dc.contributor.authorSimsek, A.
dc.contributor.authorComak, A.
dc.contributor.authorGonultas, F.
dc.contributor.authorUnal, B.
dc.contributor.authorKekilli, E.
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: There are conflicting results of studies on accuracy of positron emission tomography (PET)/computed tomography (CT) for axillary staging. The aim of this study is to determine the factors affecting the efficacy of 18F-fluorodeoxyglucose (F-18-FDG) PET/CT in detecting axillary metastases in invasive breast cancer. Materials and Methods: Data of 232 patients with invasive breast cancer who underwent F-18-FDG PET/CT examination before surgery between January 2013 and September 2017 were reviewed retrospectively. Histopathological examination of axillary lymph nodes (ALNs) was used as a reference to assess the efficacy of F-18-FDG PET/CT in detecting axillary metastases. Results: While 134 (57.8%) patients had axillary metastases as detected in F-18-FDG PET/CT scans, histopathologically axillary metastases were detected in 164 (70.7%) patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of F-18-FDG PET/CT in detection of axillary metastasis were 72.56%, 77.94%, 88.8%, 54%, and 74.1%, respectively. The false-negative and false-positive rates were 27.4% and 22%, respectively. In univariate analysis, patients' age, estrogen receptor positivity, higher ALN SUVmax, greater tumor size, and lymph node size determined by F-18-FDG PET/CT were all significantly associated with accuracy of F-18-FDG PET/CT for axillary metastasis. In multivariate analysis, tumor size determined by F-18-FDG PET/CT and ALN SUVmax were independent variables associated with axillary metastasis. The accuracy of F-18-FDG PET/CT for axillary metastasis was higher in patients with a larger tumor (>= 19.5 mm) and a higher ALN SUVmax (>= 3.2). Conclusion: F-18-FDG PET/CT should not be routinely used for axillary staging, especially in patients with small tumors. It cannot eliminiate the necessity of sentinel lymph node biopsy. When it is used, both visual information and optimal cut-off value of axillary node SUVmax should be taken into consideration.en_US
dc.description.sponsorshipAminu Kano Teaching Hospital, Kanoen_US
dc.description.sponsorshipFinancial support from the management of Aminu Kano Teaching Hospital, Kano.en_US
dc.identifier.doi10.4103/njcp.njcp_198_18
dc.identifier.endpage68en_US
dc.identifier.issn1119-3077
dc.identifier.issue1en_US
dc.identifier.pmid30666022en_US
dc.identifier.scopus2-s2.0-85060217004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_198_18
dc.identifier.urihttps://hdl.handle.net/11616/98615
dc.identifier.volume22en_US
dc.identifier.wosWOS:000462966400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAxillary metastasisen_US
dc.subjectbreast canceren_US
dc.subjectpositron emission tomographyen_US
dc.subjectcomputed tomographyen_US
dc.subjectsentinel lymph nodeen_US
dc.subjectsentinel lymph node biopsyen_US
dc.titleFactors affecting the accuracy of 18F-FDG PET/CT in evaluating axillary metastases in invasive breast canceren_US
dc.typeArticleen_US

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