Protective effect of apricot (Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.contributor.authorOzturk, Feral
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtes, Burhan
dc.contributor.authorOzturk, I. Cetin
dc.contributor.authorCetin, Asli
dc.contributor.authorVardi, Nigar
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:15Z
dc.date.available2024-08-04T20:32:15Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study was planned to investigate the protective effect of 10% and 20% apricot-containing feed on carbon tetrachloride (CCl4)-induced hepatic steatosis and damage. Adult male Wistar rats (it 42) were divided into six groups of seven each, as follows: control group; CCl4 group; CCl4 + 10% apricot group; CCl4 + 20% apricot group; 10% apricot group; 20% apricot group. All apricot groups were fed with 10% or 20% apricot-containing feed for 5 months. CCl4 injections were applied to the CCl4 groups at the dose of 1 mg/kg for 3 d at the end of 5 months. In the CCl4 group, vacuolated hepatocytes and hepatic necrosis were seen, especially in the centrilobular area. Hepatocytes showed an oedematous cytoplasmic matrix, large lipid globules and degenerated organelles. The area of liver injury was found significantly decreased with apricot feeding. Malondialdehyde and total glutathione levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. Apricot feeding decreased this oxidative stress and ameliorated histological damage. We concluded that apricot feeding had beneficial effects on CCl4-induced liver steatosis and damage probably due to its antioxidant nutrient (beta-carotene and vitamin) contents and high radical-scavenging capacity. Dietary intake of apricot can reduce the risk of liver steatosis and damage caused by free radicals.en_US
dc.description.sponsorshipInonu University Scientific Research [2005/70]; Malatya Province Apricot Research and Improvement Foundationen_US
dc.description.sponsorshipThe present study was supported by Inonu University Scientific Research Projects Unit (2005/70) and Malatya Province Apricot Research and Improvement Foundation (2006).en_US
dc.identifier.doi10.1017/S0007114509991322
dc.identifier.endpage1775en_US
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.issue12en_US
dc.identifier.pmid19822030en_US
dc.identifier.scopus2-s2.0-74949087035en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1767en_US
dc.identifier.urihttps://doi.org/10.1017/S0007114509991322
dc.identifier.urihttps://hdl.handle.net/11616/94958
dc.identifier.volume102en_US
dc.identifier.wosWOS:000273841900008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofBritish Journal of Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectApricotsen_US
dc.subjectbeta-Caroteneen_US
dc.subjectOxidative stressen_US
dc.titleProtective effect of apricot (Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar ratsen_US
dc.typeArticleen_US

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