Permeability enhancers used to increase intestinal absorption

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dc.authorscopusid56960016500
dc.authorscopusid14032701900
dc.authorscopusid57221923900
dc.contributor.authorAteş M.
dc.contributor.authorKaynak M.S.
dc.contributor.authorŞahin S.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDrugs are administered through various routes to obtain systemic effect. Of these, the most commonly used route of administration is the oral route. Following oral administration, the drug has to pass through several biological membranes until it reaches the site of effect. The most important one among these membranes is the intestinal epithelium. Absorption through the intestinal epithelium occurs mainly by two mechanisms. These mechanisms are absorption through the epithelial cell membranes (transcellular route) and absorption through the tight junctions between epithelial cells. Transport of molecules through the tight junctions is called as paracellular (intercellular) transport. The most effective way to improve drug absorption by regulating paracellular permeability is the structural organization of tight junctions. It is reported that some substances such as polymers, surfactants increase the absorption of paracellulary transported drugs across membranes by means of various mechanisms. These substances are also known as permeation enhancers. In this review, physicochemical peroperties of permeability enhancers and their mechanism of effect to increase intestinal absorption were discussed. Also various examples were given for these permeability enhancers and the studies counducted using these substances were evaluated. © 2013, Hacettepe University, Faculty of Pharmacy. All rights reserved.en_US
dc.identifier.endpage146en_US
dc.identifier.issn1300-0608
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85025104619en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://hdl.handle.net/11616/91154
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherHacettepe University, Faculty of Pharmacyen_US
dc.relation.ispartofHacettepe University Journal of the Faculty of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParacellular absorptionen_US
dc.subjectPermeabilityen_US
dc.subjectPermeation enhancersen_US
dc.titlePermeability enhancers used to increase intestinal absorptionen_US
dc.title.alternativeİntestinal absorpsiyonu artırmak amacıyla kullanılan permeasyon artırıcı ajanlaren_US
dc.typeArticleen_US

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