Erythrocyte transfusion restored heart rate variability in children with thalassemia major

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dc.authorwosidYILDIZ, SEDAT/AAB-6354-2021
dc.contributor.authorCakan, Pinar
dc.contributor.authorYildiz, Sedat
dc.contributor.authorAkyay, Arzu
dc.contributor.authorOncul, Yurday
dc.date.accessioned2024-08-04T20:50:15Z
dc.date.available2024-08-04T20:50:15Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThalassemia major (TM) is a severe transfusion-dependent anemia. Regular erytrocyte transfusion is required for the treatment of thalassemia patients. However, repeated transfusion may result in impairements in heart function. In this study, we aimed to investigate short-term effects of erythrocyte transfusion on autonomic control of heart in children with thalassemia major. For that purpose heart rate variability (HRV), which is a non-invasive method used to evaluate the effects of the autonomic nervous system on the heart rhythym, was measured before and after erythrocyte transfusion and compared to the healthy controls. Children diagnosed with TM (n = 17) and sex and age matched healthy children (HC, n = 30) were included in the study. HRV values of TM patients were measured 5 min before erythrocyte transfusion (BET, n = 17) and 5 min after erythrocyte transfusion (AET, n = 17). Parameters of time-domain and frequency-domain of HRV were evaluated in all participants. Heart rate (HR) was higher in the BET than AET (P = 0.002) but there was no difference between AET and HC groups (P > 0.05). HRV parameters were lower in BET than AET (P < 0.05) but there were no statistical difference between AET and HC (P> 0.05). The data suggest that, in thalassemia major patients, erythrocyte transfusion restores HR and HRV parameters to the levels observed in healthy controls and, thus, in short-terms, appears to be beneficial for the autonomic control of the heart.en_US
dc.identifier.doi10.1016/j.transci.2021.103156
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue4en_US
dc.identifier.pmid33985917en_US
dc.identifier.scopus2-s2.0-85106315995en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103156
dc.identifier.urihttps://hdl.handle.net/11616/99945
dc.identifier.volume60en_US
dc.identifier.wosWOS:000709808800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThalassemia majoren_US
dc.subjectChildrenen_US
dc.subjectAutonomic nervous system activityen_US
dc.subjectHeart rate variabilityen_US
dc.subjectErythrocyte transfusionen_US
dc.titleErythrocyte transfusion restored heart rate variability in children with thalassemia majoren_US
dc.typeArticleen_US

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