Strain and strain rate echocardiography in children with Wilson s disease
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cardiovascular Journal of Africa
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study aimed to evaluate strain and strain rate
echocardiography in children with Wilson’s disease to detect
early cardiac dysfunction.
Methods: In this study, 21 patients with Wilson’s disease and
a control group of 20 age- and gender-matched healthy children
were included. All the patients and the control group
were evaluated with two-dimensional (2D) and colour-coded
conventional transthoracic echocardiography by the same
paediatric cardiologist using the same echocardiography
machine (Vivid E9, GE Healthcare, Norway) in standard
precordial positions, according to the American Society of
Echocardiography recommendations. 2D strain and strain
rate echocardiography were performed after the ECG probes
of the echocardiography machine were adjusted for ECG
monitoring. Longitudinal, transverse and radial strain, and
strain rate were assessed from six basal and six mid-ventricular
segments of the left ventricle, as recommended by the
American Society of Echocardiography.
Results: Left ventricular wall thickness, systolic and diastolic
diameters, left ventricular diameters normalised to body
surface area, end-systolic and end-diastolic volumes, cardiac
output and cardiac index values were within normal limits
and statistically similar in the patient and control groups (p
> 0.05).
Global strain and strain rate: the patient group had a statistically
significant lower peak A longitudinal velocity of the
left basal point and peak E longitudinal velocity of the left
basal (VAbasR) point, and higher global peak A longitudinal/
circumferential strain rate (GSRa) compared to the corresponding
values of the control group (p < 0.05).
Radial strain and strain rate: end-systolic rotation [ROT
(ES)] was statistically significantly lower in the patient group
(p < 0.05). Longitudinal strain and strain rate: end-systolic
longitudinal strain [SLSC (ES)] and positive peak transverse
strain (STSR peak P) were statistically significantly lower in
the patient group (p < 0.05). Segmental analysis showed that rotational strain
measurement of the anterior and lateral segments of the
patient group were statistically significantly lower than
the corresponding values of the control group (p < 0.05).
Segmental analysis showed statistically significantly lower
values of end-systolic longitudinal strain [STSR (ES)] of the
basal lateral (p < 0.05) and end-systolic longitudinal strain
[SLSC (ES)] of the basal septal segment (p < 0.05) in the
patient group.
End-systolic longitudinal strain [SLSC (ES)] and positive
peak transverse strain (STSR peak P) were statistically
significantly lower in the patient group (p < 0.05). Segmental
analysis showed statistically significantly lower values of endsystolic
longitudinal strain [SLSC (ES)] of the mid-anterior
and basal anterior segments (p < 0.05), end-systolic longitudinal
strain [STSR (ES)] measurements of the posterior and
mid-posterior segments, end-systolic longitudinal displacement
[DLDC (ES)] of the basal posterior, mid-posterior and
mid-antero-septal segments in the patient group.
Conclusion: Cardiac arrhythmias, cardiomyopathy and
sudden cardiac death are rare complications but may be seen
in children with Wilson’s disease due to copper accumulation
in the heart tissue. Strain and strain rate echocardiography is
a relatively new and useful echocardiographic technique to
evaluate cardiac function and cardiac deformation abnormalities.
Our study showed that despite normal systolic function,
patients with Wilson’s disease showed diastolic dysfunction
and regional deformation abnormalities, especially rotational
strain and strain rate abnormalities.
Açıklama
Anahtar Kelimeler
2D strain, Strain rate echocardiography, Speckle tracking, Wilson’s disease
Kaynak
Cardiovascular Journal of Africa
WoS Q Değeri
Scopus Q Değeri
Cilt
27
Sayı
5
Künye
Karakurt, C. Çelik, S. F. Selimoğlu, M. A. Varol, İ. Karabiber, H. Yoloğlu, S. (2016). Strain and strain rate echocardiography in children with Wilson s disease . Cardiovascular Journal of Africa, 27 (5) ; 307-314.
