Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

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dc.authoridEren, Fatih/0000-0003-2667-8963
dc.authoridTascilar, Koray/0000-0002-8109-826X
dc.authoridMarschall, Hanns-Ulrich/0000-0001-7347-3085
dc.authoridGüzelbulut, Fatih/0000-0003-4889-208X
dc.authoridWahlin, Staffan/0000-0002-5985-9464
dc.authoridDemir, Nurhan/0000-0003-0037-7775
dc.authoridYtting, Henriette/0000-0001-5018-5232
dc.authorwosidYtting, Henriette/ABA-9518-2021
dc.authorwosidKIYICI, Murat/AAI-4213-2021
dc.authorwosidEren, Fatih/JQJ-3328-2023
dc.authorwosidChayanupatkul, Maneerat/AAX-1797-2020
dc.authorwosidTascilar, Koray/F-9070-2015
dc.authorwosidMarschall, Hanns-Ulrich/K-8842-2017
dc.authorwosidGüzelbulut, Fatih/AAF-9450-2019
dc.contributor.authorEfe, Cumali
dc.contributor.authorTascilar, Koray
dc.contributor.authorHenriksson, Ida
dc.contributor.authorLytvyak, Ellina
dc.contributor.authorAlalkim, Fatema
dc.contributor.authorTrivedi, Hirsh
dc.contributor.authorEren, Fatih
dc.date.accessioned2024-08-04T20:46:04Z
dc.date.available2024-08-04T20:46:04Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractINTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts. METHODS: We performed a study on data of 1746 UDCA-treated patients with PBC from 25 centers in Europe, United States, and Canada. The prognostic performance of the risk scoring systems (GLOBE and UK-PBC) and the UDCA response criteria (Barcelona, Paris I, Paris II, Rotterdam, and Toronto) were evaluated. We regarded cirrhosis-related complications (ascites, variceal bleeding, and/or hepatic encephalopathy) as clinical end points. RESULTS: A total of 171 patients reached a clinical end point during a median 7 years (range 1-16 years) of follow-up. The 5-, 10- and 15-year adverse outcome-free survivals were 95%, 85%, and 77%. The GLOBE and UK-PBC scores predicted cirrhosis-related complications better than the UDCA response criteria. The hazard ratio (HR) for a 1 standard deviation increase was HR 5.05 (95% confidence interval (CI): 4.43-5.74, P < 0.001) for the GLOBE score and HR 3.39 (95% CI: 3.10-3.72, P < 0.001) for the UK-PBC score. Overall, the GLOBE and UK-PBC risk scores showed similar and excellent prognostic performance (C-statistic, 0.93; 95% CI: 0.91%-95% vs 0.94; 95% CI: 0.91%-0.96%). DISCUSSION: In our international, multicenter PBC cohort, the GLOBE and UK-PBC risk scoring systems were good predictors of future cirrhosis-related complications.en_US
dc.identifier.doi10.14309/ajg.0000000000000290
dc.identifier.endpage1108en_US
dc.identifier.issn0002-9270
dc.identifier.issn1572-0241
dc.identifier.issue7en_US
dc.identifier.pmid31241547en_US
dc.identifier.scopus2-s2.0-85069274453en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1101en_US
dc.identifier.urihttps://doi.org/10.14309/ajg.0000000000000290
dc.identifier.urihttps://hdl.handle.net/11616/98874
dc.identifier.volume114en_US
dc.identifier.wosWOS:000476563000018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlacebo-Controlled Trialen_US
dc.subjectBiochemical Responseen_US
dc.subjectHistological Progressionen_US
dc.subjectCirrhosisen_US
dc.subjectBezafibrateen_US
dc.subjectPredictionen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.subjectOutcomesen_US
dc.subjectGlobeen_US
dc.titleValidation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitisen_US
dc.typeArticleen_US

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