Detecting the Shape Differences of the Corpus Callosum in Behcet's Disease by Statistical Shape Analysis

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridErcan, Ilker/0000-0002-2382-290X
dc.authorwosidSener, Serpil/ABI-6229-2020
dc.authorwosidÖZDEMİR, SENEM/AAA-8734-2021
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorColak, Cemil
dc.contributor.authorErcan, Ilker
dc.contributor.authorDogan, Metin
dc.contributor.authorOzdemir, Senem Turan
dc.contributor.authorSener, Serpil
dc.contributor.authorAlkan, Alpay
dc.date.accessioned2024-08-04T20:32:49Z
dc.date.available2024-08-04T20:32:49Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to assess the shape differences of the corpus callosum (CC) in patients with Behcet's disease using statistical shape analysis (SSA). Additionally, an attempt was made to investigate the changes in CC size according to disease duration. Twenty-five adults with clinically diagnosed Behcet's disease and 25 age-and gender-matched controls were examined by high-resolution structural magnetic resonance imaging. The data obtained from the coordinate of landmarks were analyzed with Euclidean distance matrix analysis and a thin-plate spline analysis. SSA and growth curve models were performed to investigate group differences and to fit the curves. A significant difference was determined between CC shape of Behcet patients and controls (P = 0.006). Based on the analysis, a decrease occurred in the CC size of the Behcet patients as the duration of disease increased. Maximum deformations were determined in the landmarks of interior notch of the splenium, inferior tip of the splenium, posterior-most point of the CC, and topmost point of the CC. Similarly, the landmark of anterior-most point of the CC was identified as having the minimum deformation. Behcet patients had significantly different CC shapes from control subjects. The results suggest that SSA is a promising tool for distinguishing Behcet patients from normal subjects, and that it can give useful information to assist clinicians. Additionally, SSA might be applied to detect shape differences in anatomical structures that are affected by a broad range of neurological diseases. Anat Rec, 294: 870-874, 2011. (C) 2011 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/ar.21373
dc.identifier.endpage874en_US
dc.identifier.issn1932-8486
dc.identifier.issn1932-8494
dc.identifier.issue5en_US
dc.identifier.pmid21455957en_US
dc.identifier.scopus2-s2.0-79955878199en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage870en_US
dc.identifier.urihttps://doi.org/10.1002/ar.21373
dc.identifier.urihttps://hdl.handle.net/11616/95321
dc.identifier.volume294en_US
dc.identifier.wosWOS:000289649300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnatomical Record-Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectcorpus callosumen_US
dc.subjectgeometric morphometricsen_US
dc.subjectgrowth curve modelsen_US
dc.subjectstatistical shape analysisen_US
dc.titleDetecting the Shape Differences of the Corpus Callosum in Behcet's Disease by Statistical Shape Analysisen_US
dc.typeArticleen_US

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