Decreased serum lipoprotein levels as a guide for clinical severity in patients with idiopathic dilated cardiomyopathy

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dc.authoridgüllü, hakan/0000-0003-2579-9755
dc.authorwosidgüllü, hakan/IXD-5147-2023
dc.contributor.authorSezgin, N
dc.contributor.authorSezgin, AT
dc.contributor.authorGullu, H
dc.contributor.authorKarabulut, A
dc.contributor.authorBarutcu, I
dc.contributor.authorTopal, E
dc.contributor.authorYalcintas, D
dc.date.accessioned2024-08-04T20:14:48Z
dc.date.available2024-08-04T20:14:48Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHyperlipidemia is a cardiovascular risk factor. In patients with idiopathic dilated cardiomyopathy (IDC), prognostic roles of endogenous lipoproteins are not fully clarified. It has been known that there is a direct relationship between the levels of cytokines (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) and deteriorating functional classes of heart failure and mortality. The present study compared the levels of circulating TNF-alpha, IL-6, lipoproteins, and apolipoproteins in patients with stable IDC (n = 28) with those of patients with unstable IDC (n = 26) and controls (n = 24). Mean serum total. cholesterol (TC) was significantly lower in stable IDC patients than controls (p < 0.05). In unstable IDC patients, mean serum TC was also lower than controls but not statistically significant. The IDC patients had significantly higher concentrations of IL-6 and TNF-alpha than the controls (p < 0.01). Serum IL-6 and Apo AI levels were significantly different between stable and unstable IDC patients (p = 0.021 and p = 0.012, respectively). Increased levels of IL-6 were associated with decreased levels of TC (r = -0.266, p = 0.019), LDL-C (r = -0.376, p = 0.001) and apolipoprotein AI (apo AI) (r = -0.495, p < 0.001) in all IDC patients. TNF-a was also inversely related to apo AI (r = -0.455, p < 0.001) and LDL-C (r = -0.364, p = 0.001) in all patients. Thus, elevated serum levels of cytokines in patients with IDC are associated with decreased lipoprotein concentrations, which may indicate impaired prognosis. (c) 2005 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.206.219
dc.identifier.endpage224en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.pmid15942148en_US
dc.identifier.scopus2-s2.0-21244494036en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.206.219
dc.identifier.urihttps://hdl.handle.net/11616/93980
dc.identifier.volume206en_US
dc.identifier.wosWOS:000229760700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectheart failureen_US
dc.subjectlipoproteinen_US
dc.subjectapolipoproteinen_US
dc.subjectcytokineen_US
dc.titleDecreased serum lipoprotein levels as a guide for clinical severity in patients with idiopathic dilated cardiomyopathyen_US
dc.typeArticleen_US

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