Comparison of Reproductive Toxicity Caused by Cisplatin and Novel Platinum-N-Heterocyclic Carbene Complex in Male Rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridCakir, Oguz/0000-0002-8006-2054
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidÇakır, Oğuz/CAF-8360-2022
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorBeytur, Ali
dc.contributor.authorCakir, Oguz
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:35:35Z
dc.date.available2024-08-04T20:35:35Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCisplatin and other platinum complexes are important chemotherapeutic agents and useful in the treatment for several cancers such as prostate, ovarian and testis. However, severe side effects including reproductive toxicity of cisplatin and other platinum complex cause limitations in their clinical usage. In this context, we aimed to compare the damage in testis caused by cisplatin and a novel platinum-N-heterocyclic carbene complex (Pt-NHC). To this end, 35 Sprague-Dawley rats were divided randomly into five equal groups (n = 7 in each group). Cisplatin and Pt-NHC were intraperitoneally administered as a single dose of 5 mg/kg or 10 mg/kg, and the rats were then killed 10 days after this treatment. The testicular tissues and serum samples were taken from all rats for the determination of reproductive toxicity. The results showed that cisplatin and Pt-NHC caused toxicity on the reproductive system via increased oxidative and histological damage, decreased serum testosterone levels and negatively altered sperm characteristics in a dose-dependent manner (p < 0.05). At the same dose levels, cisplatin generally caused lower toxicity on the reproductive system compared with Pt-NHC. In conclusion, these results suggest that Pt-NHC has more toxic effects on the male reproductive system than cisplatin, and in terms of clinical usage, Pt-NHC may be unsafe compared with cisplatin.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish Republic) [109T540]en_US
dc.description.sponsorshipWe acknowledge the support of TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under Grant 109T540.en_US
dc.identifier.doi10.1111/j.1742-7843.2011.00737.x
dc.identifier.endpage333en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue5en_US
dc.identifier.pmid21624060en_US
dc.identifier.scopus2-s2.0-80054071710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2011.00737.x
dc.identifier.urihttps://hdl.handle.net/11616/95459
dc.identifier.volume109en_US
dc.identifier.wosWOS:000296385500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTesticular Damageen_US
dc.subjectLycopeneen_US
dc.subjectCurcuminen_US
dc.subjectTestisen_US
dc.subjectAssayen_US
dc.titleComparison of Reproductive Toxicity Caused by Cisplatin and Novel Platinum-N-Heterocyclic Carbene Complex in Male Ratsen_US
dc.typeArticleen_US

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