Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity

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dc.authoridOZSOY, Eda Nur/0000-0003-4249-5024
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorKayhan, Elif
dc.contributor.authorDemircigil, Nursena
dc.contributor.authorOzsoy, Eda Nur
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:55:07Z
dc.date.available2024-08-04T20:55:07Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFirst in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at I(center dot)non & uuml; University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups. The experiments continued for 3 weeks and then, kidney tissues and blood samples were collected from the rats under anesthesia. Malondialdehyde (MDA), super oxidized dismutase (SOD), total oxidant status (TOS), increase in Oxidative stress index (OSI), glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase (CAT), Total antioxidant status (TAS) levels decreased in the kidney tissues collected from the tartrazine group. Serum Bun and Creatinine levels increased in the tartrazine group. Tartrazine administration damaged and degenerated the glomeruli and cortical distal tubes in the histopathology of kidney tissues, also different degrees of inflammatory cell infiltration were observed in the renal cortex and medulla. Thymoquinone and tartrazine administration improved both biochemical and histopathological parameters. Tartrazine administration induced nephrotoxicity. This could be observed with the increase in oxidant capacity and the deterioration of kidney functions. Thymoquinone was observed to demonstrate strong antioxidant properties. Thymoquinone could be used primarily as a protective agent against Tartrazine-induced toxicity.en_US
dc.identifier.doi10.1016/j.toxicon.2024.107660
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid38408527en_US
dc.identifier.scopus2-s2.0-85186515189en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2024.107660
dc.identifier.urihttps://hdl.handle.net/11616/101855
dc.identifier.volume241en_US
dc.identifier.wosWOS:001210925800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTartrazineen_US
dc.subjectThymoquinoneen_US
dc.subjectNephrotoxicityen_US
dc.subjectOxidative stressen_US
dc.subjectCaspase 3en_US
dc.titleAmeliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicityen_US
dc.typeArticleen_US

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