Protective and Therapeutic Effect of Molsidomine on Bleomycin-Induced Lung Fibrosis in Rats

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dc.authoridErmis, Hilal/0000-0002-1764-9098
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKilic, Talat/0000-0001-8125-9062
dc.authorwosidErmis, Hilal/ABI-2900-2020
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.contributor.authorKilic, Talat
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorTaslidere, Elif
dc.contributor.authorVardi, Nigar
dc.contributor.authorSarihan, Ediz
dc.contributor.authorErmis, Hilal
dc.date.accessioned2024-08-04T20:39:49Z
dc.date.available2024-08-04T20:39:49Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to investigate the preventive and treatment effect of molsidomine (MOL) on bleomycin (BLC)-induced lung injury in rats. Rats were assigned into groups as follows: control group; MOL group, 10 mg/kg MOL was continued orally for 29 day; BLC group, a single intratracheal injection of BLC (2.5 mg/kg), MOL+BLC-preventive group, 10 mg/kg MOL was administered 1 day before the intratracheal BLC injection and continued for 14 days; BLC+MOL-treatment group 10 mg/kg MOL was given on 14th day after the intratracheal BLC injection and continued until sacrifice. All animals were sacrificed on 29th day after BLC administration. The semiquantitative histopathological assessment, tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS), myeloperoxidase (MPO), and oxidative stress index (OSI) were measured. BLC-provoked histological changes were significantly detected compared to the control group. MOL restored these histological damages in different quantity in the treatment and preventive groups. BLC administration significantly decreased levels of GSH and TAS when compared to controls and these reductions was significantly ameliorated by MOL given prophylactic setting. However, therapeutic MOL administration significantly increased the TAS level decreased by BLC. The levels of MDA, MPO, and TOS were significantly increased with BLM, and these augmentations of MDA and TOS were significantly reduced by MOL given prophylactic setting. Furthermore, the OSI was higher in the BLC group, and this increase was reversed by the MOL administration before and after BLC treatment. In this study, both protective and therapeutic effects of MOL against BLC-induced lung fibrosis were demonstrated for the first time.en_US
dc.identifier.doi10.1007/s10753-014-9841-1
dc.identifier.endpage1178en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid24526289en_US
dc.identifier.scopus2-s2.0-84904730336en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1167en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-014-9841-1
dc.identifier.urihttps://hdl.handle.net/11616/96514
dc.identifier.volume37en_US
dc.identifier.wosWOS:000338725600021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbleomycinen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectinflammationen_US
dc.subjectmolsidomineen_US
dc.subjectidiopathic pulmonary fibrosisen_US
dc.titleProtective and Therapeutic Effect of Molsidomine on Bleomycin-Induced Lung Fibrosis in Ratsen_US
dc.typeArticleen_US

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