Cytotoxic Effects of Cucurbitacin I and Ecballium elaterium on Breast Cancer Cells
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natural Products Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The Cul content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identification of new molecular targets for breast cancer therapy.
Açıklama
Anahtar Kelimeler
Cucurbitacin I, Breast cancer, Ecballium elaterium, MCF-7, MDA-MB-231
Kaynak
Natural Product Communications
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
13
Sayı
11
