Cytotoxic Effects of Cucurbitacin I and Ecballium elaterium on Breast Cancer Cells

Basit Öğe Kaydı
dc.authoridKARAKUŞ, Fuat/0000-0002-5260-3650
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridÜnüvar, Songül/0000-0001-8454-490X;
dc.authorwosidKARAKUŞ, Fuat/O-2627-2019
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.authorwosidTosun, Emir/S-5125-2018
dc.contributor.authorYilmaz, Kadir
dc.contributor.authorKarakus, Fuat
dc.contributor.authorEyol, Ergul
dc.contributor.authorTosun, Emir
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorUnuvar, Songul
dc.date.accessioned2024-08-04T20:57:34Z
dc.date.available2024-08-04T20:57:34Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The Cul content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identification of new molecular targets for breast cancer therapy.en_US
dc.identifier.endpage1448en_US
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.issue11en_US
dc.identifier.startpage1445en_US
dc.identifier.urihttps://hdl.handle.net/11616/102741
dc.identifier.volume13en_US
dc.identifier.wosWOS:000456230000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatural Products Incen_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCucurbitacin Ien_US
dc.subjectBreast canceren_US
dc.subjectEcballium elateriumen_US
dc.subjectMCF-7en_US
dc.subjectMDA-MB-231en_US
dc.titleCytotoxic Effects of Cucurbitacin I and Ecballium elaterium on Breast Cancer Cellsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu