Acute and Subacute Effects of Low Versus High Doses of Standardized Panax ginseng Extract on the Heart: An Experimental Study

Basit Öğe Kaydı
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridTanriverdi, Lokman Hekim/0000-0003-4263-5234
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorOzhan, Onural
dc.contributor.authorErmis, Necip
dc.contributor.authorVardi, Nigar
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorTanriverdi, Lokman H.
dc.contributor.authorColak, Cemil
dc.date.accessioned2024-08-04T20:45:51Z
dc.date.available2024-08-04T20:45:51Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description24th National Pharmacology Congress -- NOV, 2017 -- Trabzon, TURKEYen_US
dc.description.abstractPanax ginseng is commonly used in Chinese medicine and Western herbal preparations. However, it has also been recently noted to be associated with some cardiac pathologies-including cardiogenic shock due to acute anterior myocardial infarction, trans-ischemic attack, and stent thrombosis. This study was aimed to elucidate acute and subacute effects of the low and high doses of standardized Panax ginseng extract (sPGe) on cardiac functions. Rats were randomly assigned to control group, acute low-dose group (ALD), subacute low-dose group (SALD), acute high-dose group (AHD), and subacute high-dose group (SAHD). The cardiac effects of sPGe were evaluated using hemodynamic, biochemical, echocardiographic, genetic, and immunohistopathologic parameters. Mean blood pressures were significantly lower in all sPGe-treated groups compared with the control group. Troponin I and myoglobin levels were increased in the SALD, AHD, and SAHD groups. Mitral E-wave velocity was reduced after sPGe administration in all the groups. Acidophilic cytoplasm and pyknotic nucleus in myocardial fibers were observed in AHD and SAHD groups. Cu/Zn-SOD1 gene expressions were significantly higher in the sPGe-treated groups whereas caveolin 1 and VEGF-A gene expressions were not changed. According to our results, sPGe may have a potential effect to cause cardiac damage including diastolic dysfunction, heart failure with preserved ejection fraction, and reduction of blood pressure depending on the dose and duration of usage. Healthcare professionals must be aware of adverse reactions stemming from the supplementation use, particularly with cardiac symptoms.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkeyen_US
dc.description.sponsorshipThis research is supported by a research grant from the Scientific and Technological Research Council of Turkey (Project details: 3001/115S818 belongs to Dr. Parlakpinar). Authors thank Azibe Yildiz, PhD for technical assistance and histological interpretation.en_US
dc.identifier.doi10.1007/s12012-019-09512-1
dc.identifier.endpage320en_US
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue4en_US
dc.identifier.pmid30900193en_US
dc.identifier.scopus2-s2.0-85063277350en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1007/s12012-019-09512-1
dc.identifier.urihttps://hdl.handle.net/11616/98732
dc.identifier.volume19en_US
dc.identifier.wosWOS:000475958400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofCardiovascular Toxicologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPanax ginsengen_US
dc.subjectCardiotoxicityen_US
dc.subjectStandardized extracten_US
dc.subjectHearten_US
dc.subjectRatsen_US
dc.subjectHeart failure with preserved ejection fractionen_US
dc.titleAcute and Subacute Effects of Low Versus High Doses of Standardized Panax ginseng Extract on the Heart: An Experimental Studyen_US
dc.typeConference Objecten_US

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