Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

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dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridÖzgör, Dinçer/0000-0001-8519-8869
dc.authoridGurocak, Asc Prof Simay/0000-0002-3707-5183
dc.authoridAtabek, Neslihan/0000-0002-2499-1078
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidÖzgör, Dinçer/AAB-3523-2021
dc.authorwosidGurocak, Asc Prof Simay/N-3351-2014
dc.authorwosidAtabek, Neslihan/GPP-4241-2022
dc.contributor.authorGurocak, Simay
dc.contributor.authorKarabulut, Ercan
dc.contributor.authorKaradag, Nese
dc.contributor.authorOzgor, Dincer
dc.contributor.authorOzkeles, Neslihan
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2024-08-04T20:37:43Z
dc.date.available2024-08-04T20:37:43Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest. We here aimed to evaluate whether resveratrol could protect the liver tissues from the effects of AOM. Materials and Methods: The study was conducted in 4 groups, each consisting of seven rats, the first receiving only AOM (2 times per week, 5 mg/kg), group 2 AOM and resveratrol (2 times a week, 20 mg/kg), group 3 assessed only as a control and group 4 administered only resveratrol. At the end of the seventh week, the rats were sacrificed. Rat liver MDA, NO, GSH levels were analyzed biochemically, as well as the tissues being evaluated histopathologically. Results: MDA and NO increased in AOM group as signs of increased oxidative stress. The group concomitantly administered resveratrol was been found to be significantly decreased in MDA and NO levels and increased in GSH activity. However, there were no significant findings on histopathological evaluation. Conclusions: In the light of these results, resveratrol appears to exert protective effect on oxidative stress in the liver tissue due to deleterious effects of chemical carcinogens.en_US
dc.identifier.doi10.7314/APJCP.2013.14.4.2367
dc.identifier.endpage2370en_US
dc.identifier.issn1513-7368
dc.identifier.issue4en_US
dc.identifier.pmid23725142en_US
dc.identifier.scopus2-s2.0-84880275072en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2367en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.4.2367
dc.identifier.urihttps://hdl.handle.net/11616/96137
dc.identifier.volume14en_US
dc.identifier.wosWOS:000322198700039en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectazoxymethaneen_US
dc.subjectresveratrolen_US
dc.subjectliver damageen_US
dc.titlePreventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liveren_US
dc.typeArticleen_US

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