Postoperative Pulmonary Complications After Liver Transplantation: Assessment of Risk Factors for Mortality

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dc.authoridKaragul, Servet/0000-0003-1964-2516
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidKaragul, Servet/K-3020-2015
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorAydin, C.
dc.contributor.authorOtan, E.
dc.contributor.authorAkbulut, S.
dc.contributor.authorKarakas, S.
dc.contributor.authorKayaalp, C.
dc.contributor.authorKaragul, S.
dc.contributor.authorColak, C.
dc.date.accessioned2024-08-04T20:40:18Z
dc.date.available2024-08-04T20:40:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The aim of this study was to identify the risk factors related to mortality in liver transplant (LT) patients with post-transplantation pulmonary complications. Method. Patients who underwent liver transplantation in our clinic between January 2010 and January 2012 were retrospectively reviewed for post-transplantation pulmonary complications. Demographic, clinical, radiologic, and postoperative chart data of 153 patients with pulmonary complications were analyzed using an independent samples Student t test, Pearson's chi(2) test, Fisher's exact test, and Yate's corrected chi(2) test. Mortality was analyzed using a multiple logistic regression model. The best-fit breakpoint resulting in a cut-off value for the variables of interest was determined using ROC curves and the Youden index. Results. The 153 patients with pulmonary complication were divided into 2 groups: mortality (n = 53) and survival (n = 100). Univariate analyses showed significant differences between these 2 groups with respect to MELD score (P = .035), duration of mechanical ventilation (P>.001), pneumonia (P = .01), and endotracheal culture results (P = .001). In the multivariate analysis, hemoglobin (P = .03, odds ratio [OR]: 1.239), MELD score (P = .027, OR: 1.064), duration of mechanical ventilation (P = .003, OR: 1.091), and age (P = .042, OR: 1.001) were significant risk factors for mortality. The best-fit breakpoint analysis yielded cut-off values for hemoglobin (>11.2, sensitivity: 50.9%, specificity: 70%), MELD score (>16, sensitivity: 73.6%, specificity: 42%) and duration of mechanical ventilation (>3, sensitivity: 62.3%, specificity: 76%). Conclusion. Advanced age, high hemoglobin level, high MELD score, and long-term mechanical ventilation are significant risk factors for mortality in liver transplant patients with postoperative pulmonary complications.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.058
dc.identifier.endpage1494en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093749en_US
dc.identifier.scopus2-s2.0-84931369378en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1488en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.058
dc.identifier.urihttps://hdl.handle.net/11616/96833
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800061en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespiratory Complicationsen_US
dc.titlePostoperative Pulmonary Complications After Liver Transplantation: Assessment of Risk Factors for Mortalityen_US
dc.typeArticleen_US

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