The effects of intracerebroventricular infusion of apelin 13 on reproductive function in male rats

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dc.authorid55829en_US
dc.authorid121278en_US
dc.authorid121278en_US
dc.authorid105668en_US
dc.authorid45132en_US
dc.authorid9712en_US
dc.authorid115882en_US
dc.contributor.authorSandal, Süleyman
dc.contributor.authorTekin, Suat
dc.contributor.authorSeker, Fatma Burcu
dc.contributor.authorBeytur, Ali
dc.contributor.authorVardı, Nigar
dc.contributor.authorÇolak, Cemil
dc.contributor.authorTapan, Tuba
dc.contributor.authorYıldız, Sedat
dc.contributor.authorYılmaz, Bayram
dc.date.accessioned2017-12-20T11:00:05Z
dc.date.available2017-12-20T11:00:05Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.descriptionNeuroscience Letters 602 (2015) 133–138.en_US
dc.description.abstractApelin is a novel bioactive peptide as the endogenous ligand for APJ. Apelin and APJ have also been identified in the testis, hypothalamic nuclei such as arcuate, supraoptic and paraventricular nuclei, implicating roles in the control of reproduction. Therefore, the present study was designed to investigate the effects of chronic central infusion of apelin-13 on LH, FSH and testosterone levels and testis morphology. 21 Wistar–Albino male rats received continuous intracerebroventricular infusion via Alzet osmotic mini pumps filled artificial cerebrospinal fluid (vehicle) or apelin-13 at concentrations of 1 or 10 nmol (10 l/h) for seven days. At the last 90 min of the infusion period, the blood samples were collected at 15 min intervals (0–90 min) for LH and FSH analyses. At the last sampling point, the blood samples were analyzed for testosterone levels. Infusion of high dose apelin-13 significantly suppressed LH release compared with the vehicle values at 30, 60 and 75 min (p < 0.05). However, FSH levels did not significantly differ among the groups. Serum testosterone levels in high dose apelin-13 group were statistically lower than the control group (p < 0.05). In addition, histological examination showed that infusion of high dose apelin-13 significantly decreased the number of Leydig cells compared with the control and lower dose apelin-13 groups (p < 0.05, p < 0.01). Our results suggest that apelin-13 may play a role in the central regulation and decreases testosterone release by suppressing LH secretion. Thus, antagonists of the apelin receptor may, therefore, be useful for pharmaceuticals in the treatment of infertility.en_US
dc.identifier.citationSandal, S., Tekin, S., Şeker, F. B., Beytur, A., Vardı, N., Çolak, C., … Karaman, E. (2015). The Effects Of İntracerebroventricular İnfusion Of Apelin 13 On Reproductive Function İn Male Rats. Neuroscience Letters, 602, 133–138.en_US
dc.identifier.doi10.1016/j.neulet.2015.06.059en_US
dc.identifier.endpage138en_US
dc.identifier.issue0en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://ac.els-cdn.com/S0304394015300197/1-s2.0-S0304394015300197-main.pdf?_tid=b1a6149c-e573-11e7-af71-00000aab0f6c&acdnat=1513767252_0212ec1f97084b21b865a3abe639f613
dc.identifier.urihttps://hdl.handle.net/11616/7912
dc.identifier.volume0en_US
dc.language.isoenen_US
dc.publisherNeuroscience Lettersen_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApelinen_US
dc.subjectFSHen_US
dc.subjectLHen_US
dc.subjectTestosteroneen_US
dc.subjectLeydig cellen_US
dc.subjectReproduction functionen_US
dc.titleThe effects of intracerebroventricular infusion of apelin 13 on reproductive function in male ratsen_US
dc.typeArticleen_US

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