Investigation of metabolite profiles of kidney tissues in rats treated with favipiravir drug: An NMR-based metabolomics study

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dc.contributor.authorCevik, Zeynep Rozerin
dc.contributor.authorErdogan, Ali
dc.contributor.authorMumcu, Akin
dc.contributor.authorDogan, Berat
dc.date.accessioned2026-04-04T13:34:59Z
dc.date.available2026-04-04T13:34:59Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIn response to the urgent need for effective treatments during the rapid spread and high mortality rate of COVID19, existing drugs were repurposed for potential antiviral effects, including favipiravir, originally designed as an RNA-dependent RNA polymerase inhibitor for influenza. Despite limited antiviral effectiveness against COVID19, favipiravir has been reported to cause several adverse drug events (ADEs) in the body. Recent studies have shown that favipiravir can damage various tissues in rats. However, a detailed analysis of its effects on the metabolomics profile of tissues using high-resolution spectroscopic technologies has not yet been conducted. In this study, it was aimed to analyze the metabolomic changes in rat kidney tissues induced by favipiravir, using high-resolution nuclear magnetic resonance (NMR) spectroscopy. Sixty male Wistar Albino rats were randomly divided into three groups: control, low-dose favipiravir (200 mg/kg), and high-dose favipiravir (300 mg/kg), with 20 rats per group. Each group received its respective treatment via oral gavage. After the treatment period, kidney tissue samples were collected and subjected to 1H NMR analysis. Bioinformatics analysis of the obtained 1H NMR spectra suggests that favipiravir induces dose-dependent metabolic changes in kidney tissue, with higher doses causing more profound disruptions in several pathways.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [FYL-2022-3132]; Scientific and Technological Research Council of Turkiye (TUBITAK) [120C152]
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Projects Coordination Unit, Project Number: FYL-2022-3132. Berat Dogan is supported by the Scientific and Technological Research Council of Turkiye (TUBITAK) with Project Number: 120C152.
dc.identifier.doi10.1016/j.jpba.2024.116640
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.orcid0000-0003-4810-1970
dc.identifier.pmid39705846
dc.identifier.scopus2-s2.0-85212328178
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2024.116640
dc.identifier.urihttps://hdl.handle.net/11616/109517
dc.identifier.volume255
dc.identifier.wosWOS:001392055500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectFavipiravir
dc.subjectCOVID-19
dc.subjectKidney
dc.subjectNMR
dc.subjectMetabolomics
dc.titleInvestigation of metabolite profiles of kidney tissues in rats treated with favipiravir drug: An NMR-based metabolomics study
dc.typeArticle

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