Significance and Outcome of Living-donor Liver Transplantation in Acute Mushroom Intoxication

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dc.authoridAtes, Mustafa/0000-0003-2821-453X
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authorwosidAtes, Mustafa/ABI-5100-2020
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidSAHIN, TEVFIK TOLGA/AAA-9648-2021
dc.contributor.authorBaskiran, A.
dc.contributor.authorDirican, A.
dc.contributor.authorOzgor, D.
dc.contributor.authorKement, M.
dc.contributor.authorKoc, S.
dc.contributor.authorSahin, T. T.
dc.contributor.authorAtes, M.
dc.date.accessioned2024-08-04T20:44:39Z
dc.date.available2024-08-04T20:44:39Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Mushroom intoxication ( MT) can lead to acute liver injury which may result in Mushroom intoxication-related liver failure ( M-ALF) requiring liver transplantation ( LT). In the present study, we want to share the experience of our institute regarding living-donor LT ( LDLT) due to mushroom poisoning. Aim: The aim of this study is to identify the predictors of poor prognosis in patients with ALF secondary to mushroom intoxication requiring LDLT. Materials and Methods: All patients with MT between 2008 and 2016 were evaluated. Demographics, symptoms, interval between symptoms and admission to our institute, laboratory data, model for end-stage liver disease ( MELD)/ pediatric end-stage liver disease ( PELD) scores, clinical course, and outcomes of supportive therapy and LT were evaluated. There were two groups in the study: Group A = responsive to supportive therapy ( n = 9) versus Group B = unresponsive to supportive therapy ( n = 9). Results: During the study, a total of 18 patients were admitted with M-ALF. Twelve ( 66.7%) of them were female, and the mean age was 39.9 +/- 18.2 years. All of the nine patients in Group A fully recovered with supportive therapy. In Group B, one patient died during waiting period for LT and 8 patients received LDLT LDLT. Three of the eight patients who were transplanted died in the postoperative early period within postoperative 5 days. The patients in Group B had significantly higher MELD/ PELD scores and encephalopathy rate than in Group A ( P < 0.05). International normalized ratio ( INR), bilirubin, ammonium levels, and platelet count were significantly different between groups ( P < 0.05). The patients in Group B had significantly longer interval before admission to our institute ( P < 0.05). Conclusion: The presence of encephalopathy, higher MELD/ PELD, INR, bilirubin, ammonium levels, and lower platelet count was related to poor prognosis in MT. LDLT provides a good therapeutic option in patients with M-ALF. The time is a crucial factor in successful treatment of MT. Early admission to a tertiary referral center with expertise in LT results in a better prognosis and increased survival following M-ALF.en_US
dc.identifier.doi10.4103/njcp.njcp_318_17
dc.identifier.endpage893en_US
dc.identifier.issn1119-3077
dc.identifier.issue7en_US
dc.identifier.pmid29984721en_US
dc.identifier.scopus2-s2.0-85050157731en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage888en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_318_17
dc.identifier.urihttps://hdl.handle.net/11616/98387
dc.identifier.volume21en_US
dc.identifier.wosWOS:000439047000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute liver failureen_US
dc.subjectAmanita phalloidesen_US
dc.subjectliving donor liver transplantationen_US
dc.subjectmushroom intoxicationen_US
dc.titleSignificance and Outcome of Living-donor Liver Transplantation in Acute Mushroom Intoxicationen_US
dc.typeArticleen_US

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