Risperidone and ethyl pyruvate have protective effects against ketamine-induced cognitive impairments in mice

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dc.contributor.authorKelle, I
dc.contributor.authorEriman, H.
dc.contributor.authorErdinc, M.
dc.contributor.authorUyar, E.
dc.date.accessioned2024-08-04T20:51:47Z
dc.date.available2024-08-04T20:51:47Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Ketamine, an N-methyl D-aspartic acid receptor antagonist drug, is reported to produce memory disruptions. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP), a pyruvic acid derivative, and risperidone, an atypical anti-psychotic drug, against ketamine-induced cognitive disturbances. MATERIALS AND METHODS: A passive-avoidance test, a novel object recognition test, and a modified elevated plus maze test were used to assess memory functions. Hippocampal malondialdehyde (MDA) levels were measured to determine the oxidation levels. RESULTS: Ketamine applications produced memory deficits in all tests and insignificantly increased MDA levels, which were alleviated by risperidone, EP, and combination treatments. CONCLUSIONS: Increased oxidative stress and neurotransmission imbalance can be responsible for ketamine-induced memory disruptions. With its antioxidant effects, EP may be helpful to reduce cognitive impairments related to schizophrenia either alone or in combination with antipsychotics.en_US
dc.identifier.endpage1716en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid35302220en_US
dc.identifier.scopus2-s2.0-85126721470en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1708en_US
dc.identifier.urihttps://hdl.handle.net/11616/100550
dc.identifier.volume26en_US
dc.identifier.wosWOS:000771549500037en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthyl pyruvateen_US
dc.subjectRisperidoneen_US
dc.subjectKetamineen_US
dc.subjectSchizophreniaen_US
dc.subjectCognitive symptomsen_US
dc.titleRisperidone and ethyl pyruvate have protective effects against ketamine-induced cognitive impairments in miceen_US
dc.typeArticleen_US

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