Synthesis, structural characterization, and in vitro anti-cancer activities of new phenylacrylonitrile derivatives

Basit Öğe Kaydı
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridOzen, Furkan/0000-0003-1178-1167
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidGörgülü, Ahmet Orhan/W-1964-2018
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.contributor.authorOzen, Furkan
dc.contributor.authorTekin, Suat
dc.contributor.authorKoran, Kenan
dc.contributor.authorSandal, Suleyman
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-08-04T20:42:31Z
dc.date.available2024-08-04T20:42:31Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study was designed to both synthesize phenylacrylonitrile compounds (1a-k) and their anti-tumor activities on human breast cancer cell line (MCF-7) were determined. The structures of all the compounds were defined by melting point, elemental analysis, FT-IR, H-1, C-13, C-13-APT, and HETCOR-NMR spectroscopy. Anti-tumor activities of these compounds on cell viability were evaluated using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay against MCF-7. The MCF-7 cell lines were treated with 1, 5, 25, 50, and 100 mu M concentrations of phenylacrylonitrile compounds for 24 h. At the end of the experiments, 1a, 1b, 1c, 1g, and 1h compounds reduced cell viability (p < 0.01). Additionally, the anti-cancer activities of these compounds on MCF-7 were investigated by comparing IC50 values. In conclusion, while some of the synthesized phenylacrylonitrile compounds (1a, 1b, 1c, 1g, and 1h) have antitumor activity, other phenylacrylonitrile compounds (1d, 1e, 1f, 1k, and 1h) have no effect on human breast cell lines.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [110T652]; TUBITAKen_US
dc.description.sponsorshipThis work was supported by The Scientific & Technological Research Council of Turkey (TUBITAK) (Project Number: 110T652). The authors are grateful to the Research Fund of the TUBITAK for their support.en_US
dc.identifier.doi10.1007/s13765-016-0163-x
dc.identifier.endpage248en_US
dc.identifier.issn2468-0834
dc.identifier.issn2468-0842
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84977481749en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.1007/s13765-016-0163-x
dc.identifier.urihttps://hdl.handle.net/11616/97398
dc.identifier.volume59en_US
dc.identifier.wosWOS:000377416800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKorean Soc Applied Biological Chemistryen_US
dc.relation.ispartofApplied Biological Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-tumor activityen_US
dc.subjectBreast canceren_US
dc.subjectMCF-7en_US
dc.subjectNMR-spectroscopy phenylacrylonitrileen_US
dc.titleSynthesis, structural characterization, and in vitro anti-cancer activities of new phenylacrylonitrile derivativesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu