Serum Pentraxin 3 and hs-CRP Levels in Children with Severe Pulmonary Hypertension

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dc.authoridBaspinar, Osman/0000-0002-9307-0344
dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidBaspinar, Osman/ABB-3449-2021
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorBaspinar, Osman
dc.contributor.authorCelik, Fazli Serkan
dc.contributor.authorTaskapan, Cagatay
dc.contributor.authorSahin, Aydin Derya
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:39:51Z
dc.date.available2024-08-04T20:39:51Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description2nd International Conference on Ethics Education -- MAY 21-23, 2014 -- Ankara, TURKEYen_US
dc.description.abstractBackground: Pulmonary arterial hypertension secondary to untreated left-to-right shunt defects leads to increased pulmonary blood flow, endothelial dysfunction, increased pulmonary vascular resistance, vascular remodelling, neointimal and plexiform lesions. Some recent studies have shown that inflammation has an important role in the pathophysiology of pulmonary arterial hypertension. Aims: The aim of this study is to evaluate serum pentraxin 3 and high sensitive (hs)-C reactive protein (hs-CRP) levels in children with severe pulmonary arterial hypertension (PAH) secondary to untreated congenital heart defects and evaluate the role of inflammation in pulmonary hypertension. Study Design: Cross sectional study. Methods: After ethics committee approval and receiving consent from parents, there were 31 children were selected for the study with severe PAH, mostly with a left-to-right shunt, who had been assessed by cardiac catheterisation and were taking specific pulmonary vasodilators. The control group consisted of 39 age and gender matched healthy children. After recording data about all the patients including age, gender, weight, haemodynamic studies and vasodilator testing, a physical examination was done for all subjects. Blood was taken from patients and the control group using peripheral veins to analyse serum Pentraxin 3, N-terminal pro-Brain Natriuretic Pep-tide (NT-ProBNP) and hs-CRP levels. Serum Pentraxin-3 levels were measured by enzyme linked immunosorbent assay (ELISA) and expressed as ng/mL. Serum hs-CRP levels were measured with an immunonephelometric method and expressed as mg/dL. The serum concentration of NT-proBNP was determined by a chemiluminescent immunumetric assay and expressed as pg/mL. Results: Serum Pentraxin-3 levels were determined to be 1.28 +/- 2.12 (0.12-11.43) in the PAH group (group 1) and 0.40 +/- 0.72 (0.07-3.45) in group 2. There was a statistically significant difference between the two groups (p<0.01). Serum hs-CRP levels were measured as 2.92 +/- 2.12 (0.32-14.7) mg/dL in group 1 and 0.35 +/- 0.16 (0.07-3.45) mg/dL in group 2. The hs-CRP level was increased in the PAH group to a significant degree (p<0.01). Conclusion: Our study showed that pentraxin 3 and hs-CRP levels were increased significantly in the PAH group. We consider that inflammation plays an important role in severe pulmonary hypertension and progressive pulmonary arterial hypertension in children with PAH.en_US
dc.identifier.doi10.5152/balkanmedj.2014.13307
dc.identifier.endpage223en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.pmid25625020en_US
dc.identifier.scopus2-s2.0-84907264955en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2014.13307
dc.identifier.urihttps://hdl.handle.net/11616/96556
dc.identifier.volume31en_US
dc.identifier.wosWOS:000346137300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecths-CRPen_US
dc.subjectinflammationen_US
dc.subjectpentraxin 3en_US
dc.subjectpulmonary arterial hypertensionen_US
dc.titleSerum Pentraxin 3 and hs-CRP Levels in Children with Severe Pulmonary Hypertensionen_US
dc.typeConference Objecten_US

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