Determination of serum bile acids routinely may prevent delay in diagnosis of total parenteral nutrition-induced cholestasis

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridYılmaz, Funda/0000-0003-1837-6498;
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidYılmaz, Funda/O-9646-2018
dc.authorwosidDemircan, Mehmet/AAW-7162-2020
dc.contributor.authorDemircan, M
dc.contributor.authorErgun, O
dc.contributor.authorAvanoglu, S
dc.contributor.authorYilmaz, F
dc.contributor.authorOzok, G
dc.date.accessioned2024-08-04T20:12:01Z
dc.date.available2024-08-04T20:12:01Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Porpose: Early diagnosis of development of cholestasis is a current major problem for patients receiving total parenteral nutrition (TPN). Conventional tests for hepatic function such as serum transaminases and alkaline phosphatase do not often reflect simultaneously histopathologic changes of the liver. The aim of this study is to find out the relationships between conventional hepatic function tests, total serum bile acid concentrations (TSBA), and the histopathologic changes in the liver during TPN administration in rats. Methods: Forty Albino rats were divided into four experimental groups, each consisting of 10 rats, as follows: control group (C), 0.9% saline for 14 days; T-7 group, TPN for 7 days; T-14 group, TPN for 14 days; T7O7 group, TPN for 7 days and then 0.9% saline for the next 7 days. All solutions were administered by infusion through intraperitoneal catheter in two equal doses. During the experiment, rats also maintained on rat chow and water ad libitum. Levels of serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, and TSBA were measured. Liver was evaluated histopathologically by light microscope and then Morphological Cholestasis Index (MCI) was calculated. Results: Cholestasis was present in all experimental groups except control. Levels of transaminases and alkaline phosphatase were not correlated with the histopathologic changes (P > .05), but TSBA concentrations were correlated with MCI in all groups (P < .01). TSBA concentrations and MCI in all groups also were correlated with the duration of exposure with TPN (P < .01). Conclusions: Measurement of TSBA seems to be more sensitive in early diagnosis of TPN-induced cholestasis. Therefore, periodical determination of TSBA during TPN administration can be done routinely. Copyright (C) 1999 by W.B. Saunders Company.en_US
dc.identifier.doi10.1016/S0022-3468(99)90074-X
dc.identifier.endpage567en_US
dc.identifier.issn0022-3468
dc.identifier.issue4en_US
dc.identifier.pmid10235323en_US
dc.identifier.scopus2-s2.0-0032962656en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1016/S0022-3468(99)90074-X
dc.identifier.urihttps://hdl.handle.net/11616/93169
dc.identifier.volume34en_US
dc.identifier.wosWOS:000079836000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Coen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttotal parenteral nutritionen_US
dc.subjecttotal parenteralen_US
dc.subjectnutrition-induced cholestasisen_US
dc.subjectcholestasisen_US
dc.subjectbile aciden_US
dc.subjectmorphological cholestasis indexen_US
dc.titleDetermination of serum bile acids routinely may prevent delay in diagnosis of total parenteral nutrition-induced cholestasisen_US
dc.typeArticleen_US

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