Evaluation of Culture-confirmed Extrapulmonary Tuberculosis Cases in a University Hospital

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dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authoridtoplu, sibel altunışık/0000-0002-2915-4666
dc.authoridKayabas, Uner/0000-0002-5323-0796
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidtoplu, sibel altunışık/ABH-5816-2020
dc.authorwosidKayabas, Uner/JRX-1616-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorKayabas, Uner
dc.contributor.authorOtlu, Baris
dc.contributor.authorBayindir, Yasar
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorMemisoglu, Funda
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Tuberculosis (TB) is caused by Mycobacterium tuberculosis and can involve any organ, especially the lungs. In recent years, especially in developed countries, the incidence of TB has increased due to the growing number of people with acquired immunodeficiency. This has led to an increase in the incidence of extrapulmonary TB (EPTB). This study examined patients with EPTB confirmed by positive M. tuberculosis culture in Inonu University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Molecular Microbiology Laboratory. Materials and Methods: Patients with positive M. tuberculosis culture in the molecular microbiology laboratory of our hospital between January 1, 2004 and December 31, 2014 were retrospectively evaluated according to culture-confirmed site of involvement, acid-fast bacillus (AFB), polymerase chain reaction (PCR) positivity, drug resistance, and mortality. Results: The study included 132 patients; 41 (31.1%) were male and 91 (68.9%) were female. The mean age was 46.4 +/- 18.5 (17-86) years. Extrapulmonary TB types were TB lymphadenitis in 48 patients (36.4%), musculoskeletal TB in 23 (17.4%), disseminated TB in 17 (12.9%), urinary TB in 11 (8.3%), abdominal TB in 11 (8.3%), TB meningitis in eight (6.1%), pleural TB in six (4.5%), genital TB in five (3.8%), and cutaneous TB in three patients (2.3%). Acid-fast bacillus positivity rates were 21.7% in musculoskeletal samples, 16.6% in pleural samples, 12.5% in cerebrospinal fluid, 9% in urinary tract samples, and 6.2% in lymph nodes. Polymerase chain reaction positivity was not detected in cerebrospinal fluid or skin samples. The rate of resistance to at least one anti-tuberculous drug was 20%. Mortality was 16.1% (n=9) in the 56 patients (42.4%) with available data. Conclusion: Lymphatic TB was the most common form in our patients. According to national data, pleural TB is among the common forms of EPTB in Turkey. However, the rate of pleural TB was low in our study due to the lack of pleural biopsy in our hospital during the study period. In TB-endemic regions such as Turkey, it is important to consider EPTB in the differential diagnosis of patients with relevant clinical findings and to confirm the diagnosis with TB culture primarily, as well as methods such as AFB staining and PCR.en_US
dc.identifier.doi10.4274/mjima.galenos.2019.2019.31
dc.identifier.issn2147-673X
dc.identifier.scopus2-s2.0-85113293725en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.4274/mjima.galenos.2019.2019.31
dc.identifier.urihttps://hdl.handle.net/11616/100155
dc.identifier.volume8en_US
dc.identifier.wosWOS:000579899200008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMiliary tuberculosisen_US
dc.subjectspondylodiscitisen_US
dc.subjectosteomyelitisen_US
dc.subjectepidemiologyen_US
dc.subjectmultidrug resistant tuberculosisen_US
dc.titleEvaluation of Culture-confirmed Extrapulmonary Tuberculosis Cases in a University Hospitalen_US
dc.typeArticleen_US

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