Multicentric study on malignant pleural mesothelioma in Turkey: clinicopathologic and survival characteristics of 282 patients

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dc.authoridElkıran, Emin Tamer/0000-0001-6681-7249
dc.authoridAksoy, Sercan/0000-0003-4984-1049
dc.authoridharputluoglu, hakan/0000-0001-8537-5941
dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authoridUlas, Arife/0000-0003-2918-2592
dc.authoridKaplan, Muhammet Ali/0000-0003-0882-0524
dc.authoridDEMIRCI, UMUT/0000-0002-4833-6721
dc.authorwosidElkıran, Emin Tamer/ABI-8192-2020
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidAksoy, Sercan/S-2480-2019
dc.authorwosidDogu, Gamze Gokoz/A-9815-2010
dc.authorwosidharputluoglu, hakan/ABI-6451-2020
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidUlas, Arife/HGD-4686-2022
dc.contributor.authorElkiran, Emin Tamer
dc.contributor.authorKaplan, Mehmet Ali
dc.contributor.authorSevinc, Alper
dc.contributor.authorAksoy, Sercan
dc.contributor.authorDemirci, Umut
dc.contributor.authorSeker, Mesut
dc.contributor.authorHarputluoglu, Hakan
dc.date.accessioned2024-08-04T20:37:43Z
dc.date.available2024-08-04T20:37:43Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMalignant pleural mesothelioma (MPM) is a relatively rare, but aggressive tumor that causes high mortality. The major risk factor involved in the etiology is environmental and occupational exposure to asbestos. The optimal modality of therapy is controversial. The present study retrospectively evaluated the data pertinent to 282 patients who were examined and treated in 11 different medical oncology centers in Turkey. There were 161 males (57.1 %) and 121 females (42.9 %), with a mean age of 56.38 +/- A 12.07 years. Surgery was used in 74 patients, 21 patients (28.4 %) received only chemotherapy and 28 patients (37.8 %) received chemoradiotherapy after surgery. The median survival in patients who were administered adjuvant therapy after surgery was 24 months, while the median survival in patients who had only surgery was 6 months (p = 0.029). 106 patients were administered pemetrexed-platinum combination and 35 patients were administered gemcitabine-platinum combination as front-line chemotherapy. Median survival, 1- and 2-year survival rates in patients who received platinum analogues and pemetrexed or gemcitabine combinations were found statistically similar (p = 0.15). The median survival for all patients with MPM in our study was 18 months. The main factors influencing the overall survival were stage of the disease (p = 0.020), performance status (p < 0.001), asbestos exposure (p = 0.030) and mesothelioma histological subtypes (p < 0.001). Results of our study suggest that multi-modality treatment regimens consisting of surgery, radiotherapy and chemotherapy prolong overall survival. Survival rates in patients who received combining platinum analogues with pemetrexed or gemcitabine as front-line chemotherapy were found similar.en_US
dc.identifier.doi10.1007/s12032-012-0276-y
dc.identifier.endpage3154en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue5en_US
dc.identifier.pmid22722923en_US
dc.identifier.scopus2-s2.0-84880276941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3147en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-012-0276-y
dc.identifier.urihttps://hdl.handle.net/11616/96138
dc.identifier.volume29en_US
dc.identifier.wosWOS:000311513800022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalignant pleural mesotheliomaen_US
dc.subjectAsbestos exposureen_US
dc.subjectMulti-modality treatmenten_US
dc.subjectFront-line chemotherapyen_US
dc.subjectPrognostic factorsen_US
dc.titleMulticentric study on malignant pleural mesothelioma in Turkey: clinicopathologic and survival characteristics of 282 patientsen_US
dc.typeArticleen_US

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