Dose-dependent subacute cardiovascular effects of modafinil in rats

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTanriverdi, Lokman Hekim/0000-0003-4263-5234
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridKaraca, Yücel/0000-0002-5184-5308
dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTanriverdi, Lokman Hekim/M-5701-2015
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidKaraca, Yücel/AAA-4477-2022
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.contributor.authorCanyurt, Dilan
dc.contributor.authorTanriverdi, Lokman Hekim
dc.contributor.authorOzhan, Onural
dc.contributor.authorCansel, Mehmet
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.contributor.authorCigremis, Yilmaz
dc.date.accessioned2024-08-04T20:48:46Z
dc.date.available2024-08-04T20:48:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractModafinil is used for the treatment of various sleep disorders; however, its usage among healthy individuals is also increasing. There are a limited number of cardiovascular side effects, including ischemic T-wave changes, dyspnea, hypertension, and tachycardia in the literature. Our research aimed to investigate the dose-dependent subacute cardiovascular effects of modafinil in rats. Thirty-two rats were randomly and equally assigned to a control group (vehicle-treated for 14 days), a subacute low-dose group (SALD, 10 mg/kg for 14 days), a subacute moderate-dose group (SAMD, 100 mg/kg for 14 days), and a subacute high-dose group (SHD, 600 mg/kg for 14 days). The cardiovascular effects of modafinil were evaluated using hemodynamic, biochemical, electrocardiographic, electrophysiologic, and histopathologic parameters. In terms of hemodynamic parameters, heart rate, and systolic/diastolic/mean blood pressure levels, electrophysiological parameters did not reach statistical significance among the groups (p > 0.05). The incidence of T-wave negativity in SAMD and SAHD groups was 25 and 37.5%, respectively. Moreover, one rat per group was affected by an atrioventricular blockage. Malondialdehyde, superoxide dismutase, catalase, and reduced glutathione levels in the heart and vascular tissues, serum troponin-I, and creatine kinase levels were similar between the modafinil-administered groups and the control group (p > 0.05); this indicates that modafinil activated neither oxidative stress nor antioxidant pathway. Also, there was no difference in histopathological parameters between groups (p > 0.05). Supratherapeutic doses of modafinil may have the potential to cause ischemic cardiac damage and atrioventricular blockage, despite inconsistency with literature findings; however, this does not pertain to hemodynamic changes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [1919B011603861]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey under Grant [number 1919B011603861].en_US
dc.identifier.doi10.1080/01480545.2020.1803906
dc.identifier.endpage1053en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid32777970en_US
dc.identifier.scopus2-s2.0-85089255851en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1044en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1803906
dc.identifier.urihttps://hdl.handle.net/11616/99452
dc.identifier.volume45en_US
dc.identifier.wosWOS:000557962700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrioventricular blockageen_US
dc.subjectcardiotoxicityen_US
dc.subjectdrug toxicityen_US
dc.subjectexperimental toxicologyen_US
dc.subjectmodafinilen_US
dc.titleDose-dependent subacute cardiovascular effects of modafinil in ratsen_US
dc.typeArticleen_US

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