The protective effect of erdosteine on short-term global brain ischemia/reperfusion injury in rats

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dc.authoridBilgic, Sedat/0000-0001-8410-2685
dc.authorwosidBİLGİÇ, Sedat/AEM-2044-2022
dc.authorwosidbilgiç, sedat/JVN-5459-2024
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.contributor.authorOzerol, Elif
dc.contributor.authorBilgic, Sedat
dc.contributor.authorIraz, Mustafa
dc.contributor.authorCigli, Ahmet
dc.contributor.authorIlhan, Atilla
dc.contributor.authorAkyol, Omer
dc.date.accessioned2024-08-04T20:31:06Z
dc.date.available2024-08-04T20:31:06Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractExperimental studies have demonstrated that free radicals play a major role on neuronal injury during ischemia/reperfusion (I/R) in rats. Erdosteine is a thioderivative endowed with mucokinetic, mucolytic and free-radical-scavenging properties. The aim of the present study was to investigate the effect of erdosteine treatment against short-term global brain ischemia/reperfusion injury in rats. The study was carried out on Wistar rats divided into four groups. (i) Control group, (ii) ischemia/reperfusion group, (iii) ischemia/reperfusion + erdosteine group, and (iv) erdosteine group. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats. Plasma NO levels were significantly higher in the ischemia/reperfusion group than the other groups. The activities of SOD and GSH-Px were decreased, while TBARS levels increased in the ischemia/reperfusion group compared to other groups in both plasma and erythrocyte. The erythrocyte CAT activity was higher in erdosteine group and there was a statistically significant increase, when compared with the erdosteine plus ischemia/reperfusion group. By treating the rats with erdosteine, the depletion of endogenous antioxidant enzymes (SOD, CAT, GSH-Px) and increase of TBARS and NO levels were prevented. This study, therefore, suggests that erdosteine reduces parameters of oxidative stress is well supported by the data. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2008.09.024
dc.identifier.endpage24en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue1en_US
dc.identifier.pmid18930779en_US
dc.identifier.scopus2-s2.0-58149343751en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2008.09.024
dc.identifier.urihttps://hdl.handle.net/11616/94725
dc.identifier.volume33en_US
dc.identifier.wosWOS:000263212200004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectErdosteineen_US
dc.subjectFree radicalsen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectOxidative injuryen_US
dc.titleThe protective effect of erdosteine on short-term global brain ischemia/reperfusion injury in ratsen_US
dc.typeReview Articleen_US

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