Hypochlorous acid for accidental vincristine overdose: A preliminary experimental study

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dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.contributor.authorOzgen, U
dc.contributor.authorStout, M
dc.contributor.authorTurkoz, Y
dc.contributor.authorOzugurlu, F
dc.contributor.authorKutlu, NO
dc.contributor.authorSoylu, H
dc.contributor.authorKoltuksuz, U
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: to investigate the potential efficacy of in vivo treatment of accidental vincristine (VCR) overdose using hypochlorous acid (HOCl). Methods: 24 New Zealand rabbits were divided into 4 groups as control, HOCl-treated, VCR + treated and HOCl + VCR-treated, and their clinical and laboratory indexes were examined. Results: there were no clinical and laboratory abnormalities observed in control and HOCl group subjects. All rabbits died after quadriplegia and respiratory insufficiency in VCR and HOCl + VCR groups. Bone marrow suppression was more pronounced and onset of the neurotoxicity was early in VCR group compared to HOCl + VCR group subjects. Serum half-life of VCR was lower in HOCl + VCR group animals suggesting a contribution of HOCl in eliminating VCR resulting in the observed clinical and laboratory differences in these two groups. Conclusion: although further research is necessary, our results indicate a potential role for HOCl in the treatment of accidental VCR overdose.en_US
dc.identifier.endpage300en_US
dc.identifier.issn1812-9269
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0742271089en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://hdl.handle.net/11616/93733
dc.identifier.volume25en_US
dc.identifier.wosWOS:000188745400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst Exp Pathol Oncol Radiobiolen_US
dc.relation.ispartofExperimental Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvincristine overdoseen_US
dc.subjectneurotoxicityen_US
dc.subjecthypochlorous aciden_US
dc.subjectexperimental animalsen_US
dc.titleHypochlorous acid for accidental vincristine overdose: A preliminary experimental studyen_US
dc.typeArticleen_US

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