Coiled-coil domain-containing protein-124 (Ccdc124) is a novel RNA binding factor up-regulated in endometrial, ovarian, and urinary bladder cancers

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dc.authoridArslan, Özge/0000-0001-9515-494X
dc.authoridTAZEBAY, UYGAR HALIS/0000-0003-1999-8213
dc.authorwosidArslan, Özge/ABL-0270-2022
dc.contributor.authorArslan, Ozge
dc.contributor.authorSoylu, Nese Karadag
dc.contributor.authorAkillilar, Pelin Telkoparan
dc.contributor.authorTazebay, Uygar H.
dc.date.accessioned2024-08-04T20:50:23Z
dc.date.available2024-08-04T20:50:23Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Coiled-coil domain containing protein-124 (Ccdc124) is a putative mRNA-binding factor associated with cell division, and ribosome biology. Previous reports mentioned an up-regulation of CCDC124 gene in cancer, and listed its mRNA in a molecular prognostic signature in breast cancer. OBJECTIVES: Establishing RNA-binding characteristics of Ccdc124 for a better molecular functional characterization, and carrying-out retrospective studies in order to evaluate its aberrant expression in human cancer samples from various tissue origins. METHODS: Bioinformatics calculations followed by RIP and RNA-seq experiments were performed to investigate mRNA targets of Ccdc124. Quantitative studies on arrays of cDNAs from different cancers and IHC assays on tissue arrays were used to assess CCDC124 expression levels in cancers. RESULTS: Ccdc124 was characterized as an RNA-binding protein (RBP) interacting with various mRNAs. CCDC124 mRNA levels were high in tumors, with a particular up-regulation in cancers from esophagus, adrenal gland, endometrium, liver, ovary, thyroid, and urinary bladder. IHC assays indicated strong Ccdc124 positivity in endometrial (95.4%), urinary bladder (68.4%), and ovarian cancers (86.8%). CONCLUSION: Ccdc124 is a cytokinesis related RBP interacting with various mRNAs. CCDC124 mRNA over-expression and an accompanied increase in Ccdc124 protein accumulation was reported in cancers, indicating this RBP as a novel cancer cell marker.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research Council (TUBITAK) [KBAG 114-Z-349]; Ministry of Development [2014-K-120430]en_US
dc.description.sponsorshipThe present study was funded by grants from Turkish Scientific and Technological Research Council (TUBITAK) KBAG 114-Z-349 to U.H.T., and by Ministry of Development 2014-K-120430 to Gebze Technical University Centre Research Laboratory (GTUMAR).en_US
dc.identifier.doi10.3233/CBM-200802
dc.identifier.endpage164en_US
dc.identifier.issn1574-0153
dc.identifier.issn1875-8592
dc.identifier.issue2en_US
dc.identifier.pmid33896821en_US
dc.identifier.scopus2-s2.0-85108915103en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.3233/CBM-200802
dc.identifier.urihttps://hdl.handle.net/11616/100012
dc.identifier.volume31en_US
dc.identifier.wosWOS:000668394800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofCancer Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer biomarkersen_US
dc.subjectcoiled-coil domain-containing protein-124en_US
dc.subjectRNA-binding proteinsen_US
dc.subjectgynecological cancersen_US
dc.subjectovarian canceren_US
dc.subjecturinary bladder canceren_US
dc.titleCoiled-coil domain-containing protein-124 (Ccdc124) is a novel RNA binding factor up-regulated in endometrial, ovarian, and urinary bladder cancersen_US
dc.typeArticleen_US

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