Increased micronucleus frequencies in peripheral blood lymphocytes in women with polycystic ovary syndrome

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dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridYESILADA, ERDEM/0000-0002-1348-6033
dc.authoridYILDIRIM, İBRAHİM HALİL/0000-0001-5518-5004
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidYildirim, Ibrahim/ABF-6466-2021
dc.authorwosidyıldırım, ibrahim/IAQ-5372-2023
dc.contributor.authorYesilada, E
dc.contributor.authorSahin, I
dc.contributor.authorOzcan, H
dc.contributor.authorYildirim, IH
dc.contributor.authorYologlu, S
dc.contributor.authorTaskapan, C
dc.date.accessioned2024-08-04T20:15:24Z
dc.date.available2024-08-04T20:15:24Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We aimed to assess possible genomic instability in women with polycystic ovary syndrome (PCOS). Design: The frequency of micronuclei in cultured peripheral lymphocytes was used as a biomarker of genomic instability in somatic cells. Methods: Nineteen women, diagnosed with PCOS and 19 healthy female volunteers of corresponding ages and body-mass index (BMI) were included in the study. Micronuclei frequencies were assessed in cytokinesis-blocked lymphocytes. Results: The frequency of micronucleated cells (per thousand) was 9.00 (5.00) (interquartile range in parentheses) for patient group and 3.0 (3.0) for the control group (P < 0.0001, Mann-Whitney U-test). The serum levels of follicle-stimulating hormone (FSH), estradiol, prolactin, glucose and dehydroepiandrosterone sulfate (DHEAS) and the homeostasis model of assessment of insulin resistance (HOMA-IR) were not different between the two groups (P > 0.05). Serum total testosterone, luteinizing hormone (LH) and insulin levels and hirsutism score in the PCOS group were significantly (P = 0.007, P < 0.0001, P = 0.009 and P < 0.0001 respectively) higher than those of the control group (2.3 (2.1) nmol/l vs 1.7 (0.4) nmol/l; 8.5 (5.88) mU/ml vs 4.8 (4.4) mU/ml; 6.8 (5.1.) mu U/ml vs 9.7 (4.2) mu U/ml; 19.5 (6.5) vs 4.0 (2.5) respectively). However, the mean level of sex hormone-binding globulin (SHBG) in PCOS group was significantly (P = 0.004) lower than in control group (36.4(22.6) nmol/l vs 48.6(25.2) nmol/l respectively). Conclusion: These findings suggest that women with PCOS have a high incidence of genomic instability, and this condition is positively correlated with the hirsutism score, BMI. LH and serum total testosterone and insulin levels, and is negatively correlated with SHBG.en_US
dc.identifier.doi10.1530/eje.1.02117
dc.identifier.endpage568en_US
dc.identifier.issn0804-4643
dc.identifier.issue4en_US
dc.identifier.pmid16556719en_US
dc.identifier.scopus2-s2.0-33646047399en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1530/eje.1.02117
dc.identifier.urihttps://hdl.handle.net/11616/94366
dc.identifier.volume154en_US
dc.identifier.wosWOS:000236851100009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBio Scientifica Ltden_US
dc.relation.ispartofEuropean Journal of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectCancer-Patientsen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectGenetic-Basisen_US
dc.subjectYoung-Womenen_US
dc.subjectDna-Damageen_US
dc.subjectRisken_US
dc.subjectPrevalenceen_US
dc.titleIncreased micronucleus frequencies in peripheral blood lymphocytes in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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