Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease

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dc.authoridDuzova, Ali/0000-0002-4365-2995
dc.authoridÇalışkan, Salim/0000-0002-3316-8032
dc.authoridCakar, Nilgun/0000-0002-1853-0101
dc.authoridCANPOLAT, NUR/0000-0002-3420-9756
dc.authoridAnton-Gamero, Montserrat/0000-0002-8515-4900
dc.authoridOzcelik, Gul/0000-0001-9394-2977
dc.authoridLitwin, Mieczyslaw/0000-0002-5241-2483
dc.authorwosidCandan, Cengiz/ABC-6193-2021
dc.authorwosidTkaczyk, Marcin/M-6079-2014
dc.authorwosidHarambat, Jérôme/T-1371-2019
dc.authorwosidDuzova, Ali/AAB-7692-2021
dc.authorwosidÇalışkan, Salim/ABC-1479-2020
dc.authorwosidCortina, Gerard/AAH-6198-2019
dc.authorwosidCakar, Nilgun/AAI-1121-2020
dc.contributor.authorLerch, Christian
dc.contributor.authorShroff, Rukshana
dc.contributor.authorWan, Mandy
dc.contributor.authorRees, Lesley
dc.contributor.authorAitkenhead, Helen
dc.contributor.authorBulut, Ipek Kaplan
dc.contributor.authorThurn, Daniela
dc.date.accessioned2024-08-04T20:45:31Z
dc.date.available2024-08-04T20:45:31Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. We investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD). Methods. In all, 80 vitamin D-deficient children were selected: 40 with mild to moderate CKD from the ERGO study, a randomized trial of ergocalciferol supplementation [ estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m(2)], and 40 with advanced CKD from the observational Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study (eGFR 24 mL/min/1.73 m2). In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls. Measures were taken at baseline and after a median period of 8 months. Age- and gender-related standard deviation scores (SDSs) were calculated. Results. Before vitamin D supplementation, children in the ERGO study had normal FGF23 (median 0.31 SDS) and BAP (-0.10 SDS) but decreased Klotho and sclerostin (-0.77 and -1.04 SDS, respectively), whereas 4C patients had increased FGF23 (3.87 SDS), BAP (0.78 SDS) and sclerostin (0.76 SDS) but normal Klotho (-0.27 SDS) levels. Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients. BAP levels were unchanged in all patients. In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m(2). Conclusions. Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.en_US
dc.description.sponsorshipEuropean Society for Pediatric Nephrology [ESPN 2014.3]; KfH Foundation for Preventive Medicine; ERA-EDTAen_US
dc.description.sponsorshipThis work was supported by the European Society for Pediatric Nephrology (reference number ESPN 2014.3), KfH Foundation for Preventive Medicine and ERA-EDTA (to D.H.).en_US
dc.identifier.doi10.1093/ndt/gfy012
dc.identifier.endpage2217en_US
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.issue12en_US
dc.identifier.pmid29481636en_US
dc.identifier.scopus2-s2.0-85055965206en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2208en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/gfy012
dc.identifier.urihttps://hdl.handle.net/11616/98519
dc.identifier.volume33en_US
dc.identifier.wosWOS:000456608400017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbone and mineral metabolismen_US
dc.subjectchildrenen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectvitamin D deficiencyen_US
dc.subjectvitamin D supplementationen_US
dc.titleEffects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney diseaseen_US
dc.typeArticleen_US

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