The effects of acrylamide and vitamin E on kidneys in pregnancy: An experimental study

Basit Öğe Kaydı
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorGül, Mehmet
dc.contributor.authorYiğitcan, Birgül
dc.contributor.authorÇanta, Harika Gozukara
dc.contributor.authorAltınöz, E.
dc.contributor.authorTürköz, Yusuf
dc.date.accessioned2019-07-29T10:14:38Z
dc.date.available2019-07-29T10:14:38Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The objective of this study is to investigate possible damages to kidney tissues of pregnant rats and their fetuses exposed to acrylamide during pregnancy and possible protective effects of vitamin E against these damages. Material and methods: Rats were randomly assigned to five groups of control, corn oil, vitamin E, acrylamide, vitamin E + acrylamide, six pregnant rats in each. Mother and fetal kidney tissues were examined for malondialdehyde (MDA), reductase glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS), urea, creatine, trace elements such as Zn and Cu in the serum and histopathological analyses were conducted. Results: It was determined that acrylamide, administered during pregnancy, statistically significantly increased MDA and TOS levels, maternal serum urea, creatinine, and Zn levels, while it decreased GSH, TAS, SOD, and CAT levels (p ≤ .05) when compared with all other groups in the kidney tissues of pregnant rats and their fetuses and caused tubular degeneration, hemorrhage, narrowing, and closure in Bowman’s space, and, in the E vitamin group, it statistically significantly increased GSH, TAS, SOD, CAT, urea, creatinine, and Zn levels when compared with other groups and lowered TOS and MDA levels to those of the control group (p < .05) and there were no differences between the groups histologically. Conclusion: It was observed that acrylamide administered during pregnancy caused oxidative stress in kidney tissues of mother rats and their fetuses, resulting in tissue damage, and vitamin E application, which is considered to be a powerful antioxidant, inhibited oxidative stress.en_US
dc.identifier.citationAksungur, Z. Gül, M. Yiğitcan, B. Çanta, HG. Altınöz, E. Türköz, Y. (2018). The effects of acrylamide and vitamin E on kidneys in pregnancy: An experimental study. 1-10 ss.en_US
dc.identifier.doi10.1080/14767058.2018.1471675en_US
dc.identifier.endpage10en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11616/13032
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectfetusen_US
dc.subjectkidneysen_US
dc.subjectmotheren_US
dc.subjectoxidative stressen_US
dc.subjectpregnancyen_US
dc.subjectvitamin Een_US
dc.titleThe effects of acrylamide and vitamin E on kidneys in pregnancy: An experimental studyen_US
dc.typeArticleen_US

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