Bioactive NHC-derived palladium complexes: synthesis, catalytic activity for the Suzuki-Miyaura coupling of aryl chlorides and bromides and their antibacterial activities

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dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidabutaha, nael/AAX-4443-2021
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidHarrath, Abdel Halim/K-2166-2014
dc.contributor.authorBoubakri, Lamia
dc.contributor.authorAl-Ayed, Abdullah S.
dc.contributor.authorMansour, L.
dc.contributor.authorAbutaha, Nael
dc.contributor.authorHarrath, Abdel Halim
dc.contributor.authorOzdemir, I
dc.contributor.authorYasar, S.
dc.date.accessioned2024-08-04T20:46:53Z
dc.date.available2024-08-04T20:46:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPd(II)-bis(NHC) complexes (where NHC = N-heterocyclic carbene) bearing asymmetrically and symmetrically substituted NHC-ligand have been synthesized via deprotonation of 5,6-dimethylbenzimidazolium salts. The NHC precursors have been achieved via the two step N-alkylation of 5,6-dimethylbenzimidazole. The resultant salts were deprotonated with PdCl2 and K2CO3 in dry THF for 2(a-e). The obtained complexes were identified and characterized by H-1 and C-13 NMR, FT-IR, DART-TOF mass spectrometry and elemental analysis. These new Pd(II)-bis(NHC) complexes were applied as catalyst precursors for Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid to afford the corresponding products in good yields. This catalytic reaction was evaluated in the presence of KOtBu/toluene. The antibacterial activities of 2(a-e) were investigated against Gram (+)/(-) bacteria using the agar dilution procedure. The antibacterial activities of 2 vary with the nature of the ligands; MIC values of 2(a-e) were determined.en_US
dc.description.sponsorshipResearch Supporting Project, King Saud University, Riyadh, Saudi Arabia [RSP-2019/75]en_US
dc.description.sponsorshipThis work was funded by the Research Supporting Project (RSP-2019/75), King Saud University, Riyadh, Saudi Arabien_US
dc.identifier.doi10.1080/00958972.2019.1664738
dc.identifier.endpage2704en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue16en_US
dc.identifier.scopus2-s2.0-85074052782en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2688en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2019.1664738
dc.identifier.urihttps://hdl.handle.net/11616/99001
dc.identifier.volume72en_US
dc.identifier.wosWOS:000487442600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSuzuki-Miyaura couplingen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectPd(II)-bis(NHC) catalysten_US
dc.subjectantibacterial activityen_US
dc.titleBioactive NHC-derived palladium complexes: synthesis, catalytic activity for the Suzuki-Miyaura coupling of aryl chlorides and bromides and their antibacterial activitiesen_US
dc.typeArticleen_US

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