Cardiovascular impact of consumption of sulfured-dried Malatya apricots (Prunus armeniaca L.) at varying SO2 levels: A comprehensive assessment in a rat model

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dc.contributor.authorAyik, Seyhan
dc.contributor.authorYildiz, Azibe
dc.contributor.authorOzhan, Onural
dc.contributor.authorKaraca, Yucel
dc.contributor.authorTaslidere, Elif
dc.contributor.authorErmis, Necip
dc.contributor.authorVardi, Nigar
dc.date.accessioned2026-04-04T13:35:08Z
dc.date.available2026-04-04T13:35:08Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractApricots known as sulfured-dried are those dried under the sun with sulfur dioxide (SO2), which extends their shelf life. Although sun-dried apricots are renowned for their cardiovascular benefits, the cardiovascular effects of sulfured-dried apricots (SDAs) remain poorly understood. To address this knowledge gap, we designed the present study to investigate the cardiovascular effects of consuming SDAs at varying SO2 levels in a rat model. The rats were randomly assigned to 6 groups. The Control group received standard rat chow, while the other 5 groups were fed a diet containing 10 % SDAs with differing SO2 concentrations (1500 ppm, 2000 ppm, 2500 ppm, 3000 ppm, and 3500 ppm) for 24 weeks. After echocardiography and hemodynamic assessment, cardiac histopathology and serum biochemistry were evaluated. Our findings indicate that an SDA diet containing 3500 ppm SO2 leads to myocardial damage and subsequent cardiac dysfunction, likely through TNF-alpha-mediated inflammation and apoptosis. In contrast, diets containing SDAs with SO2 levels between 1500 and 2500 ppm appeared to pose minimal cardiovascular risk. Because in these groups, there was no evidence of myocardial damage, cardiac inflammation, apoptotic cell death, or cellular stress in the cardiac myocytes. Also, these groups showed normal cardiac function in echocardiographic assessments. These results suggest that consuming SDAs with SO2 concentrations up to 2500 ppm SO2 may be safe for cardiovascular health.
dc.description.sponsorshipInonu University Scientific Research Unit [TSG-2019-1637]
dc.description.sponsorshipThis study was supported by the Inonu University Scientific Research Unit (No. TSG-2019-1637) .
dc.identifier.doi10.1016/j.fct.2025.115654
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.orcid0000-0002-8766-9094
dc.identifier.orcid0000-0002-9040-4249
dc.identifier.pmid40706980
dc.identifier.scopus2-s2.0-105011515585
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fct.2025.115654
dc.identifier.urihttps://hdl.handle.net/11616/109625
dc.identifier.volume204
dc.identifier.wosWOS:001545305900004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectApoptosis
dc.subjectDried apricot
dc.subjectHeart
dc.subjectHemodynamics
dc.subjectImmunohistochemistry
dc.subjectInflammation
dc.subjectSulfur dioxide
dc.titleCardiovascular impact of consumption of sulfured-dried Malatya apricots (Prunus armeniaca L.) at varying SO2 levels: A comprehensive assessment in a rat model
dc.typeArticle

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