The Experience of Ibrutinib in Chronic Graft-Versus-Host Disease in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Single Center Experience

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dc.authoridkaplan, sidika gulkan/0000-0001-5917-8071
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridTanriverdi, Lokman Hekim/0000-0003-4263-5234
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridBERBER, Ilhami/0000-0003-3312-8476
dc.authorwosidkaplan, sidika gulkan/ADX-4886-2022
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidTanriverdi, Lokman Hekim/M-5701-2015
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidBERBER, Ilhami/ABI-6231-2020
dc.contributor.authorSarici, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBerber, Ilhami
dc.contributor.authorBicim, Soykan
dc.contributor.authorHidayet, Emine
dc.date.accessioned2024-08-04T20:11:42Z
dc.date.available2024-08-04T20:11:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Chronic graft-versus host disease (GVHD) is a serious complication that develops in 35-50% of patients in the late period after allogeneic hematopoetic stem cell transplantation. About half of the patients are resistant to corticosteroids, which is the first-line treatment of chronic GVHD, and therefore new treatment options that can be effective in chronic GVHD are needed. In the present study, we aimed to share our experience with the use of ibrutinib therapy in patients with steroid-resistant chronic GVHD who have previously received multiple lines of systemic therapy. Methods: The characteristics and clinical outcomes of steroid-resistant chronic patients with GVHD receiving ibrutinib were retrospectively reviewed. Results: A total of 10 steroid resi-stant chronic patients with GVHD who received ibrutinib was included. While 50% of the patients had more than one organ involvement, 50% had a single organ involvement. The most commonly affected organs were the skin and liver. The patients received a median of three lines of systemic therapy before ibrutinib. After a median of 210 days of ibrutinib usage, the complete response rate of patients was 40% and the partial response rate was 40%. Corticosteroids were completely discontinued in 30% of patients after ibrutinib were initiated. Before ibrutinib, patients were given a median of 0.3 mg/kg methylprednisolone. The median methylprednisolone dose after ibrutinib was 0.03 mg/kg. Conclusion: Ibrutinib therapy causes a quite high overall response in steroid resistant chronic patients with GVHD and appears to be a good option in these patients.en_US
dc.identifier.doi10.4274/imj.galenos.2023.98370
dc.identifier.endpage220en_US
dc.identifier.issn2619-9793
dc.identifier.issn2148-094X
dc.identifier.issue2en_US
dc.identifier.startpage216en_US
dc.identifier.trdizinid1179518en_US
dc.identifier.urihttps://doi.org/10.4274/imj.galenos.2023.98370
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1179518
dc.identifier.urihttps://hdl.handle.net/11616/92930
dc.identifier.volume24en_US
dc.identifier.wosWOS:001000376900020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofIstanbul Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSteroid-resistant graft-versus host diseaseen_US
dc.subjectibrutiniben_US
dc.subjectcorticosteroidsen_US
dc.subjectallo-HSCTen_US
dc.subjectchronic GVHDen_US
dc.titleThe Experience of Ibrutinib in Chronic Graft-Versus-Host Disease in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Single Center Experienceen_US
dc.typeArticleen_US

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