DNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosis

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dc.authoridFoxman, Betsy/0000-0001-6682-238X
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authoridHebert, Andrea/0000-0001-8174-3129
dc.authorwosidZhang, Li/GWM-7501-2022
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidFoxman, Betsy/E-1836-2015
dc.contributor.authorHebert, Andrea M.
dc.contributor.authorTalarico, Sarah
dc.contributor.authorYang, Dong
dc.contributor.authorDurmaz, Riza
dc.contributor.authorMarrs, Carl F.
dc.contributor.authorZhang, Lixin
dc.contributor.authorFoxman, Betsy
dc.date.accessioned2024-08-04T20:30:38Z
dc.date.available2024-08-04T20:30:38Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTuberculosis continues to be a leading cause of death worldwide. Development of an effective vaccine against Mycobacterium tuberculosis is necessary to reduce the global burden of this disease. Mtb72F, consisting of the protein products of the pepA and PPE18 genes, is the first subunit tuberculosis vaccine to undergo phase I clinical trials. To obtain insight into the ability of Mtb72F to induce an immune response capable of recognizing different strains of M. tuberculosis, we investigated the genomic diversity of the pepA and PPE18 genes among 225 clinical strains of M. tuberculosis from two different geographical locations, Arkansas and Turkey, representing a broad range of genotypes of M. tuberculosis. A combination of single nucleotide polymorphisms (SNPs) and insertion/deletions resulting in amino acid changes in the PPE18 protein occurred in 47 (20.9%) of the 225 study strains, whereas SNPs resulted in amino acid changes in the PepA protein in 14 (6.2%) of the 225 study strains. Of the 122 Arkansas study strains and the 103 Turkey study strains, 32 (26.2%) and 15 (14.6%), respectively, had at least one genetic change leading to an alteration of the amino acid sequence of the PPE18 protein, and many of the changes occurred in regions previously reported to be potential T-cell epitopes. Thus, immunity induced by Mtb72F may not recognize a proportion of M. tuberculosis clinical strains.en_US
dc.description.sponsorshipNIAID NIH HHS [R01-AI151975] Funding Source: Medlineen_US
dc.identifier.doi10.1128/IAI.00335-07
dc.identifier.endpage5805en_US
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.issue12en_US
dc.identifier.pmid17893137en_US
dc.identifier.scopus2-s2.0-36749010689en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5798en_US
dc.identifier.urihttps://doi.org/10.1128/IAI.00335-07
dc.identifier.urihttps://hdl.handle.net/11616/94409
dc.identifier.volume75en_US
dc.identifier.wosWOS:000251341500030en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Soc Microbiologyen_US
dc.relation.ispartofInfection and Immunityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyprotein Vaccineen_US
dc.subjectImmune-Responsesen_US
dc.subjectMtb72fen_US
dc.subjectBcgen_US
dc.subjectRecommendationsen_US
dc.subjectPopulationen_US
dc.subjectRelevanceen_US
dc.subjectGenomicsen_US
dc.subjectAntigensen_US
dc.subjectInsightsen_US
dc.titleDNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosisen_US
dc.typeArticleen_US

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