Effect of the treatment of brucellosis on leukocyte superoxide dismutase activity and plasma nitric oxide level

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorKarabulut, AB
dc.contributor.authorSonmez, E
dc.contributor.authorBayindir, Y
dc.date.accessioned2024-08-04T20:13:49Z
dc.date.available2024-08-04T20:13:49Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The mechanisms by which brucellae evade intracellular killing by polymorphonuclear leukocytes are incompletely understood. In this study, we evaluated changes of leukocyte superoxide dismutase (SOD) activity and plasma total nitrite as an indicator of nitric oxide (NO) levels during brucellosis therapy. Methods: Thirty-two patients with acute brucellosis, 27 patients with chronic brucellosis and 30 healthy controls were included in the study. Patients with acute brucellosis were tested for leukocyte SOD activity and plasma total nitrite levels before, during (21st day), and at the end (45th day) of the combined therapy of rifampicin and doxycycline. The same parameters were also investigated in chronic cases and controls. Results: The SOD activities were lower in patients with acute brucellosis before therapy compared with those 21 and 45 days after starting therapy (P < 0.001). In contrast, total nitrite levels did not change significantly (P > 0.05). Conclusions: In the present study, leukocyte SOD activity was found to be decreased in patients with acute brucellosis. Enzyme activity was increased by treatment, finally reaching the activity of healthy controls. Using an antioxidant agent in addition to classical antimicrobial therapy for acute brucellosis might be a therapeutic approach.en_US
dc.identifier.endpage132en_US
dc.identifier.issn0004-5632
dc.identifier.issn1758-1001
dc.identifier.pmid15829122en_US
dc.identifier.scopus2-s2.0-17144380856en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://hdl.handle.net/11616/93874
dc.identifier.volume42en_US
dc.identifier.wosWOS:000228457200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAnnals of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords]en_US
dc.titleEffect of the treatment of brucellosis on leukocyte superoxide dismutase activity and plasma nitric oxide levelen_US
dc.typeArticleen_US

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